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Molecules 2010, 15(6), 4401-4407; doi:10.3390/molecules15064401
Communication

Preparation and Physicochemical Properties of the Complex of Naringenin with Hydroxypropyl-β-Cyclodextrin

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Received: 5 May 2010 / Revised: 7 June 2010 / Accepted: 9 June 2010 / Published: 18 June 2010
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Abstract

In this study a complex of naringenin with hydroxypropyl-β-cyclodextrin (HP-β-CD) was prepared to improve the hydrophilicity of naringenin. The physicochemical properties of the complex were analyzed by ultraviolet-visible spectrometry (UV), infrared spectrometry (IR), X-ray diffractometry (XRD), differential scanning calorimetry (DSC). The result showed that naringenin had been molecularly dispersed in the HP-β-CD matrix, not forming a new compound and HPLC analysis showed that the solubility of naringenin in water was enhanced from 4.38 μg/mL to 1,272.31 μg/mL.
Keywords: naringenin; hydroxypropyl-β-cyclodextrin; complex; flavonoid naringenin; hydroxypropyl-β-cyclodextrin; complex; flavonoid
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Wen, J.; Liu, B.; Yuan, E.; Ma, Y.; Zhu, Y. Preparation and Physicochemical Properties of the Complex of Naringenin with Hydroxypropyl-β-Cyclodextrin. Molecules 2010, 15, 4401-4407.

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