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Molecules 2010, 15(6), 4033-4040; doi:10.3390/molecules15064033

Synthesis and in vitro Cytotoxicity of Novel Ursolic Acid Derivatives

Department of Pharmaceutical Engineering, Shenyang University of Chemical Technology, Iiaoning 110042, China
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Received: 21 April 2010 / Revised: 13 May 2010 / Accepted: 26 May 2010 / Published: 4 June 2010
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Abstract

In an effort to improve potential hepatoprotective and anti-tumor activities, eight novel ursolic acid (UA) derivatives were designed and synthesized with substitution at positions of C-3, C-11and C-28 of UA. Their structures were confirmed using IR, MS and 1H-NMR and elemental analysis. Their in vitro cytotoxicity against various cancer cell lines (HeLa, SKOV3 and BGC-823) was evaluated by the standard MTT assay. Among them, compound 13 exhibited more potent cytotoxicity than ursolic acid.
Keywords: ursolic acid derivatives; structure modification; anti-tumor activity ursolic acid derivatives; structure modification; anti-tumor activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Meng, Y.; Song, Y.; Yan, Z.; Xia, Y. Synthesis and in vitro Cytotoxicity of Novel Ursolic Acid Derivatives. Molecules 2010, 15, 4033-4040.

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