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Molecules 2010, 15(6), 4033-4040; doi:10.3390/molecules15064033

Synthesis and in vitro Cytotoxicity of Novel Ursolic Acid Derivatives

* , * ,
Department of Pharmaceutical Engineering, Shenyang University of Chemical Technology, Iiaoning 110042, China
* Authors to whom correspondence should be addressed.
Received: 21 April 2010 / Revised: 13 May 2010 / Accepted: 26 May 2010 / Published: 4 June 2010
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In an effort to improve potential hepatoprotective and anti-tumor activities, eight novel ursolic acid (UA) derivatives were designed and synthesized with substitution at positions of C-3, C-11and C-28 of UA. Their structures were confirmed using IR, MS and 1H-NMR and elemental analysis. Their in vitro cytotoxicity against various cancer cell lines (HeLa, SKOV3 and BGC-823) was evaluated by the standard MTT assay. Among them, compound 13 exhibited more potent cytotoxicity than ursolic acid.
Keywords: ursolic acid derivatives; structure modification; anti-tumor activity ursolic acid derivatives; structure modification; anti-tumor activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Meng, Y.; Song, Y.; Yan, Z.; Xia, Y. Synthesis and in vitro Cytotoxicity of Novel Ursolic Acid Derivatives. Molecules 2010, 15, 4033-4040.

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