Thionation of Some α,β-Unsaturated Steroidal Ketones
AbstractThe reactions of selected α,β-unsaturated steroidal ketones with Lawesson’s reagent (LR) in CH2Cl2 and toluene under the standard reaction conditions and with a combination of phosphorus pentasulfide with hexamethyldisiloxane (P4S10/HMDO) in 1,2-dichlorobenzene (ODCB) under microwave irradiation were investigated and for this purpose several cholestane, androstane and pregnane carbonyl derivatives were chosen. Depending on the reagent and the solvent, 19 new sulfur containing compounds, including dithiones 4c and 4d, α,β-unsaturated 3-thiones 3a-e, dimer-sulfides 2a-e, 1,2,4-trithiolanes 5a-e and phosphonotrithioates 6b-e were synthesized. All newly prepared compounds were characterized by IR, 1H- and 13C-NMR spectroscopy and elemental analysis.
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Krstić, N.M.; Bjelaković, M.S.; Dabović, M.M.; Pavlović, V.D. Thionation of Some α,β-Unsaturated Steroidal Ketones. Molecules 2010, 15, 3462-3477.
Krstić NM, Bjelaković MS, Dabović MM, Pavlović VD. Thionation of Some α,β-Unsaturated Steroidal Ketones. Molecules. 2010; 15(5):3462-3477.Chicago/Turabian Style
Krstić, Natalija M.; Bjelaković, Mira S.; Dabović, Milan M.; Pavlović, Vladimir D. 2010. "Thionation of Some α,β-Unsaturated Steroidal Ketones." Molecules 15, no. 5: 3462-3477.