Molecules 2010, 15(4), 2551-2563; doi:10.3390/molecules15042551
Article

Organocatalytic Michael Addition of 1,3-Dicarbonyl Indane Compounds to Nitrostyrenes

Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou 310012, China
* Authors to whom correspondence should be addressed.
Received: 9 December 2009; in revised form: 3 March 2010 / Accepted: 19 March 2010 / Published: 12 April 2010
(This article belongs to the Special Issue Asymmetric Synthesis)
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Abstract: To map out the efficient organocatalyst requirements in the Michael addition of 1,3-dicarbonyl indane compounds to nitrostyrenes, a dozen different amino organocatalysts containing a p-toluenesulfonyl group (Ts) have been evaluated; excellent enantio-selectivities (up to er 92:8) were obtained with a primary amine-based Ts-DPEN catalyst and a plausible catalytic reaction mechanism was proposed on the basis of the experimental results.
Keywords: organocatalysis; Michael reaction; primary amine; diamine

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MDPI and ACS Style

Jiang, Z.-Y.; Yang, H.-M.; Ju, Y.-D.; Li, L.; Luo, M.-X.; Lai, G.-Q.; Jiang, J.-X.; Xu, L.-W. Organocatalytic Michael Addition of 1,3-Dicarbonyl Indane Compounds to Nitrostyrenes. Molecules 2010, 15, 2551-2563.

AMA Style

Jiang Z-Y, Yang H-M, Ju Y-D, Li L, Luo M-X, Lai G-Q, Jiang J-X, Xu L-W. Organocatalytic Michael Addition of 1,3-Dicarbonyl Indane Compounds to Nitrostyrenes. Molecules. 2010; 15(4):2551-2563.

Chicago/Turabian Style

Jiang, Zhen-Yu; Yang, Hua-Meng; Ju, Ya-Dong; Li, Li; Luo, Meng-Xian; Lai, Guo-Qiao; Jiang, Jian-Xiong; Xu, Li-Wen. 2010. "Organocatalytic Michael Addition of 1,3-Dicarbonyl Indane Compounds to Nitrostyrenes." Molecules 15, no. 4: 2551-2563.

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