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Molecules 2010, 15(4), 2499-2508; doi:10.3390/molecules15042499
Article

Synthesis and Antimicrobial Activity of Novel Ag-N-Hetero-cyclic Carbene Complexes

1,* , 1
, 2
 and 1,*
1 Department of Chemistry, Faculty of Science and Art, İnönü University, 44280 Malatya, Turkey 2 Department of Microbiology, Faculty of Medicine, İnönü University, 44280 Malatya, Turkey
* Authors to whom correspondence should be addressed.
Received: 16 March 2010 / Revised: 29 March 2010 / Accepted: 7 April 2010 / Published: 8 April 2010
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Abstract

A series of imidazolidinium ligand precursors are metallated with Ag2O to give silver(I) N-heterocyclic carbene complexes. All compounds were fully characterized by elemental analyses, 1H-NMR, 13C-NMR and IR spectroscopy techniques. All compounds studied in this work were screened for their in vitro antimicrobial activities against the standard strains: Enterococcus faecalis (ATCC 29212), Staphylococcus aureus (ATCC 29213), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853) and the fungi Candida albicans and Candida tropicalis. The new imidazolidin-2-ylidene silver complexes have been found to display effective antimicrobial activity against a series of bacteria and fungi.
Keywords: N-Heterocyclic carbene; silver complexes; antimicrobial activity; imidazolidin-2-ylidene N-Heterocyclic carbene; silver complexes; antimicrobial activity; imidazolidin-2-ylidene
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Özdemir, İ.; Özcan, E.Ö.; Günal, S.; Gürbüz, N. Synthesis and Antimicrobial Activity of Novel Ag-N-Hetero-cyclic Carbene Complexes. Molecules 2010, 15, 2499-2508.

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