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Synthesis and Antimicrobial Activity of Novel Ag-N-Hetero-cyclic Carbene Complexes
Department of Chemistry, Faculty of Science and Art, İnönü University, 44280 Malatya, Turkey
Department of Microbiology, Faculty of Medicine, İnönü University, 44280 Malatya, Turkey
* Authors to whom correspondence should be addressed.
Received: 16 March 2010; in revised form: 29 March 2010 / Accepted: 7 April 2010 / Published: 8 April 2010
Abstract: A series of imidazolidinium ligand precursors are metallated with Ag2O to give silver(I) N-heterocyclic carbene complexes. All compounds were fully characterized by elemental analyses, 1H-NMR, 13C-NMR and IR spectroscopy techniques. All compounds studied in this work were screened for their in vitro antimicrobial activities against the standard strains: Enterococcus faecalis (ATCC 29212), Staphylococcus aureus (ATCC 29213), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853) and the fungi Candida albicans and Candida tropicalis. The new imidazolidin-2-ylidene silver complexes have been found to display effective antimicrobial activity against a series of bacteria and fungi.
Keywords: N-Heterocyclic carbene; silver complexes; antimicrobial activity; imidazolidin-2-ylidene
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MDPI and ACS Style
Özdemir, İ.; Özcan, E.Ö.; Günal, S.; Gürbüz, N. Synthesis and Antimicrobial Activity of Novel Ag-N-Hetero-cyclic Carbene Complexes. Molecules 2010, 15, 2499-2508.
Özdemir İ, Özcan EÖ, Günal S, Gürbüz N. Synthesis and Antimicrobial Activity of Novel Ag-N-Hetero-cyclic Carbene Complexes. Molecules. 2010; 15(4):2499-2508.
Özdemir, İlknur; Özcan, Emine Özge; Günal, Selami; Gürbüz, Nevin. 2010. "Synthesis and Antimicrobial Activity of Novel Ag-N-Hetero-cyclic Carbene Complexes." Molecules 15, no. 4: 2499-2508.