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Molecules 2010, 15(4), 2453-2472; doi:10.3390/molecules15042453
Article

Bifunctional Catalysis: Direct Reductive Amination of Aliphatic Ketones with an Iridium-Phosphate Catalyst

1
, 1, 2, 2 and 1,*
Received: 9 March 2010; in revised form: 29 March 2010 / Accepted: 2 April 2010 / Published: 8 April 2010
(This article belongs to the Special Issue Bifunctional Catalysis)
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Abstract: Chiral amines are one of the ubiquitous functional groups in fine chemical, pharmaceutical and agrochemical products, and the most convenient, economical, and eco-benign synthetic pathway to these amines is direct asymmetric reductive amination (DARA) of prochiral ketones. This paper shows that a wide range of aliphatic ketones can be directly aminated under hydrogenation conditions, affording chiral amines with good to excellent yields and with enantioselectivities up to 96% ee. The catalysis is effected by the cooperative action of a cationic Cp*Ir(III) complex and its phosphate counteranion.
Keywords: reductive amination; asymmetric hydrogenation; bifunctional catalyst; aliphatic ketones; chiral amines reductive amination; asymmetric hydrogenation; bifunctional catalyst; aliphatic ketones; chiral amines
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Villa-Marcos, B.; Li, C.; Mulholland, K.R.; Hogan, P.J.; Xiao, J. Bifunctional Catalysis: Direct Reductive Amination of Aliphatic Ketones with an Iridium-Phosphate Catalyst. Molecules 2010, 15, 2453-2472.

AMA Style

Villa-Marcos B, Li C, Mulholland KR, Hogan PJ, Xiao J. Bifunctional Catalysis: Direct Reductive Amination of Aliphatic Ketones with an Iridium-Phosphate Catalyst. Molecules. 2010; 15(4):2453-2472.

Chicago/Turabian Style

Villa-Marcos, Barbara; Li, Chaoqun; Mulholland, Keith R.; Hogan, Philip J.; Xiao, Jianliang. 2010. "Bifunctional Catalysis: Direct Reductive Amination of Aliphatic Ketones with an Iridium-Phosphate Catalyst." Molecules 15, no. 4: 2453-2472.


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