Abstract: Thermogravimetry (TG) and differential scanning calorimetry (DSC) are useful techniques that have been successfully applied in the pharmaceutical industry to reveal important information regarding the physicochemical properties of drug and excipient molecules such as polymorphism, stability, purity, formulation compatibility among others. Verapamil hydrochloride shows thermal stability up to 180 °C and melts at 146 °C, followed by total degradation. The drug is compatible with all the excipients evaluated. The drug showed degradation when subjected to oxidizing conditions, suggesting that the degradation product is 3,4-dimethoxybenzoic acid derived from alkyl side chain oxidation. Verapamil hydrochloride does not present the phenomenon of polymorphism under the conditions evaluated. Assessing the drug degradation kinetics, the drug had a shelf life (t90) of 56.7 years and a pharmaceutical formulation showed t90 of 6.8 years showing their high stability.
Keywords: verapamil hydrochloride; thermal analysis; degradation kinetics; characterization
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Yoshida, M.I.; Gomes, E.C.L.; Soares, C.D.V.; Cunha, A.F.; Oliveira, M.A. Thermal Analysis Applied to Verapamil Hydrochloride Characterization in Pharmaceutical Formulations. Molecules 2010, 15, 2439-2452.
Yoshida MI, Gomes ECL, Soares CDV, Cunha AF, Oliveira MA. Thermal Analysis Applied to Verapamil Hydrochloride Characterization in Pharmaceutical Formulations. Molecules. 2010; 15(4):2439-2452.
Yoshida, Maria Irene; Gomes, Elionai Cassiana Lima; Soares, Cristina Duarte Vianna; Cunha, Alexandre Frinhani; Oliveira, Marcelo Antonio. 2010. "Thermal Analysis Applied to Verapamil Hydrochloride Characterization in Pharmaceutical Formulations." Molecules 15, no. 4: 2439-2452.