Molecules 2010, 15(4), 2427-2438; doi:10.3390/molecules15042427
Article

Synthesis and Antimicrobial Activities of Some New 1,2,4-Triazole Derivatives

Hakan Bektaş 1 , Nesrin Karaali 1 , Deniz Şahin 1 , Ahmet Demirbaş 1 , Şengül Alpay Karaoglu 2  and Neslihan Demirbaş 1,* email
1 Department of Chemistry, Karadeniz Technical University, 61080 Trabzon, Turkey 2 Department of Biology, Rize University, 53100 Rize, Turkey
* Author to whom correspondence should be addressed.
Received: 12 February 2010; in revised form: 9 March 2010 / Accepted: 22 March 2010 / Published: 8 April 2010
PDF Full-text Download PDF Full-Text [223 KB, uploaded 8 April 2010 13:54 CEST]
Abstract: Some novel 4,5-disubstituted-2,4-dihydro-3H-1,2,4-triazol-3-one (3, 6, 8, 9) derivatives and or 3-(4-methylphenyl)[1,2,4]triazolo[3,4-b][1,3]benzoxazole (5) were synthesized from the reaction of various ester ethoxycarbonylhydrazones (1a-e) with several primary amines. The synthesis of 4-amino-5-(4-chlorophenyl)-2-[(5-mercapto-1,3,4-oxadiazol-2-yl)methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one (13) was performed starting from 4-Amino-5-(4-chlorophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one (2) by four steps; then 13 was converted to the corresponding Schiff base (14) by using 4-methoxybenzaldehyde. Finally, two Mannich base derivatives of 14 were obtained by using morpholine or methyl piperazine as amine component. All newly synthesized compounds were screened for their antimicrobial activities and some of which were found to possess good or moderate activities against the test microorganisms.
Keywords: 1,2,4-Triazole; triazolo[3,4-b][1,3]benzoxazole;primary amine; Schiff base; Mannich base

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Bektaş, H.; Karaali, N.; Şahin, D.; Demirbaş, A.; Karaoglu, Ş.A.; Demirbaş, N. Synthesis and Antimicrobial Activities of Some New 1,2,4-Triazole Derivatives. Molecules 2010, 15, 2427-2438.

AMA Style

Bektaş H, Karaali N, Şahin D, Demirbaş A, Karaoglu ŞA, Demirbaş N. Synthesis and Antimicrobial Activities of Some New 1,2,4-Triazole Derivatives. Molecules. 2010; 15(4):2427-2438.

Chicago/Turabian Style

Bektaş, Hakan; Karaali, Nesrin; Şahin, Deniz; Demirbaş, Ahmet; Karaoglu, Şengül Alpay; Demirbaş, Neslihan. 2010. "Synthesis and Antimicrobial Activities of Some New 1,2,4-Triazole Derivatives." Molecules 15, no. 4: 2427-2438.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert