Next Article in Journal
Controlled Release of 5-Aminosalicylic Acid (5-ASA) from New Biodegradable Polyurethanes
Previous Article in Journal
The Heck Reaction in Ionic Liquids: Progress and Challenges
Molecules 2010, 15(4), 2246-2256; doi:10.3390/molecules15042246
Article

Synthesis and Antimicrobial Activity of New 4-Heteroarylamino Coumarin Derivatives Containing Nitrogen and Sulfur as Heteroatoms

1, 2,* , 1
,
3
 and
2
1 Department of Chemistry, Faculty of Science and Mathematics, University of Priština, Lole Ribara 29, 38220 Kosovska Mitrovica, Serbia 2 Department of Chemistry, Faculty of Science and Mathematics, University of Niš, Višegradska 33, 18000 Niš, Serbia 3 Department of Chemistry, Faculty of Science, University of Kragujevac, R. Domanovića 12, 34000 Kragujevac, Serbia
* Author to whom correspondence should be addressed.
Received: 17 March 2010 / Revised: 26 March 2010 / Accepted: 29 March 2010 / Published: 30 March 2010
Download PDF [278 KB, uploaded 18 June 2014]   |  

Abstract

Synthesis, spectral analysis and bioactivity of new coumarin derivatives are described in this paper. Eight new coumarin derivatives were synthesized in moderate to good yields by condensation of 4-chloro-3-nitrocoumarin and the corresponding heteroarylamine. The synthesized compounds were tested for their in vitro antimicrobial activity, in a standard disk diffusion assay, against thirteen strains of bacteria and three fungal strains. They have shown a wide range of activity - from one completely inactive compound to medium active ones.
Keywords: 4-heteroarylaminocoumarins; synthesis; 4-chloro-3-nitrocoumarin; spectral analysis; antimicrobial activity 4-heteroarylaminocoumarins; synthesis; 4-chloro-3-nitrocoumarin; spectral analysis; antimicrobial activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Dekić, B.R.; Radulović, N.S.; Dekić, V.S.; Vukićević, R.D.; Palić, R.M. Synthesis and Antimicrobial Activity of New 4-Heteroarylamino Coumarin Derivatives Containing Nitrogen and Sulfur as Heteroatoms. Molecules 2010, 15, 2246-2256.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert