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Molecules 2010, 15(4), 2246-2256; doi:10.3390/molecules15042246
Article

Synthesis and Antimicrobial Activity of New 4-Heteroarylamino Coumarin Derivatives Containing Nitrogen and Sulfur as Heteroatoms

1, 2,* , 1
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Received: 17 March 2010; in revised form: 26 March 2010 / Accepted: 29 March 2010 / Published: 30 March 2010
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Abstract: Synthesis, spectral analysis and bioactivity of new coumarin derivatives are described in this paper. Eight new coumarin derivatives were synthesized in moderate to good yields by condensation of 4-chloro-3-nitrocoumarin and the corresponding heteroarylamine. The synthesized compounds were tested for their in vitro antimicrobial activity, in a standard disk diffusion assay, against thirteen strains of bacteria and three fungal strains. They have shown a wide range of activity - from one completely inactive compound to medium active ones.
Keywords: 4-heteroarylaminocoumarins; synthesis; 4-chloro-3-nitrocoumarin; spectral analysis; antimicrobial activity 4-heteroarylaminocoumarins; synthesis; 4-chloro-3-nitrocoumarin; spectral analysis; antimicrobial activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Dekić, B.R.; Radulović, N.S.; Dekić, V.S.; Vukićević, R.D.; Palić, R.M. Synthesis and Antimicrobial Activity of New 4-Heteroarylamino Coumarin Derivatives Containing Nitrogen and Sulfur as Heteroatoms. Molecules 2010, 15, 2246-2256.

AMA Style

Dekić BR, Radulović NS, Dekić VS, Vukićević RD, Palić RM. Synthesis and Antimicrobial Activity of New 4-Heteroarylamino Coumarin Derivatives Containing Nitrogen and Sulfur as Heteroatoms. Molecules. 2010; 15(4):2246-2256.

Chicago/Turabian Style

Dekić, Biljana R.; Radulović, Niko S.; Dekić, Vidoslav S.; Vukićević, Rastko D.; Palić, Radosav M. 2010. "Synthesis and Antimicrobial Activity of New 4-Heteroarylamino Coumarin Derivatives Containing Nitrogen and Sulfur as Heteroatoms." Molecules 15, no. 4: 2246-2256.


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