Two new polyynes, named oplopantriol A (
5) and oplopantriol B (
6), were isolated from the root bark of
Oplopanax horridus (Smith) Miq, an ethnic medicinal plant of North America, along with four known polyynes: (3
S,8
S)-falcarindiol
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Two new polyynes, named oplopantriol A (
5) and oplopantriol B (
6), were isolated from the root bark of
Oplopanax horridus (Smith) Miq, an ethnic medicinal plant of North America, along with four known polyynes: (3
S,8
S)-falcarindiol (
1), oplopandiol (
2), (11
S,16
S,9
Z)-9,17-octadecadiene-12,14-diyne-1,11,16-triol, 1-acetate (
3) and oplopandiol acetate (
4). The structures of the new compounds were elucidated by detailed spectroscopic analyses, including 1D and 2D NMR techniques and chemical methods. The absolute configurations of the new compounds
5 and
6 were determined by comparing their optical rotation values with the hydrolysis products of the known compounds
3 and
4, respectively, derived from the same plant. On the basis of an analysis of their physical and chemical properties we show that the alkaline hydrolysis of
3 and
4 afforded the new compounds
5 and
6, respectively.
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