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Molecules 2010, 15(2), 842-856; doi:10.3390/molecules15020842
Article

Seeking Polymeric Prodrugs of Norfloxacin. Part 2. Synthesis and Structural Analysis of Polyurethane Conjugates

Marcin Sobczak * email, Katarzyna Nurzyńska email and Waclaw Kolodziejski email
Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, ul. Banacha 1, 02-097 Warsaw, Poland
* Author to whom correspondence should be addressed.
Received: 11 January 2010; in revised form: 30 January 2010 / Accepted: 3 February 2010 / Published: 5 February 2010
(This article belongs to the Special Issue Prodrugs)
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Abstract: Oligo(ε-caprolactone) and oligolactide were synthesized via ring-opening polymerization of cyclic esters in the presence of creatinine as initiators. Thus obtained oligomers were successfully used in the synthesis of novel polyurethane conjugates of norfloxacin. The structures of the polymers and conjugates were elucidated by means of MALDI-TOF MS, NMR and IR studies.
Keywords: aliphatic polyesters; aliphatic polyurethanes; ring-opening polymerization; macromolecular conjugates; prodrugs of norfloxacin

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MDPI and ACS Style

Sobczak, M.; Nurzyńska, K.; Kolodziejski, W. Seeking Polymeric Prodrugs of Norfloxacin. Part 2. Synthesis and Structural Analysis of Polyurethane Conjugates. Molecules 2010, 15, 842-856.

AMA Style

Sobczak M., Nurzyńska K., Kolodziejski W. Seeking Polymeric Prodrugs of Norfloxacin. Part 2. Synthesis and Structural Analysis of Polyurethane Conjugates. Molecules. 2010; 15(2):842-856.

Chicago/Turabian Style

Sobczak, Marcin; Nurzyńska, Katarzyna; Kolodziejski, Waclaw. 2010. "Seeking Polymeric Prodrugs of Norfloxacin. Part 2. Synthesis and Structural Analysis of Polyurethane Conjugates." Molecules 15, no. 2: 842-856.

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