Molecules 2010, 15(2), 766-779; doi:10.3390/molecules15020766
Article

Synthesis and Crystal Structure of Novel Sulfone Derivatives Containing 1,2,4-Triazole Moieties

Weiming Xuemail, Baoan Song* email, Pinaki Bhaduryemail, Yang Songemail and Deyu Huemail
Key Laboratory of Green Pesticide and Agriculture Bioengineering, Ministry of Education, Research and Development Center for Fine Chemicals, Guizhou University, Guiyang 550025, China
* Author to whom correspondence should be addressed.
Received: 5 November 2009; in revised form: 25 January 2010 / Accepted: 29 January 2010 / Published: 3 February 2010
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Abstract: Some 3-(Substituted methylthio)-4-phenyl-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazole derivatives were synthesized in six steps starting from easily accessible gallic acid. The resulting sulfides were then catalytically oxidized to the title sulfones with H2O2. The products were obtained in high yield under mild conditions and practically devoid of any by-products. The structures were confirmed by elemental analysis, IR, 1H- and 13C-NMR spectral data. Furthermore, a detailed X-ray crystallography structural analysis of model triazole 7g was carried out.
Keywords: sulfone derivatives; 1,2,4-triazole; sodium tungstate; hydrogen peroxide; synthesis; crystal structure

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MDPI and ACS Style

Xu, W.; Song, B.; Bhadury, P.; Song, Y.; Hu, D. Synthesis and Crystal Structure of Novel Sulfone Derivatives Containing 1,2,4-Triazole Moieties. Molecules 2010, 15, 766-779.

AMA Style

Xu W, Song B, Bhadury P, Song Y, Hu D. Synthesis and Crystal Structure of Novel Sulfone Derivatives Containing 1,2,4-Triazole Moieties. Molecules. 2010; 15(2):766-779.

Chicago/Turabian Style

Xu, Weiming; Song, Baoan; Bhadury, Pinaki; Song, Yang; Hu, Deyu. 2010. "Synthesis and Crystal Structure of Novel Sulfone Derivatives Containing 1,2,4-Triazole Moieties." Molecules 15, no. 2: 766-779.

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