Molecules 2010, 15(2), 766-779; doi:10.3390/molecules15020766
Article

Synthesis and Crystal Structure of Novel Sulfone Derivatives Containing 1,2,4-Triazole Moieties

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Received: 5 November 2009; in revised form: 25 January 2010 / Accepted: 29 January 2010 / Published: 3 February 2010
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Some 3-(Substituted methylthio)-4-phenyl-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazole derivatives were synthesized in six steps starting from easily accessible gallic acid. The resulting sulfides were then catalytically oxidized to the title sulfones with H2O2. The products were obtained in high yield under mild conditions and practically devoid of any by-products. The structures were confirmed by elemental analysis, IR, 1H- and 13C-NMR spectral data. Furthermore, a detailed X-ray crystallography structural analysis of model triazole 7g was carried out.
Keywords: sulfone derivatives; 1,2,4-triazole; sodium tungstate; hydrogen peroxide; synthesis; crystal structure
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MDPI and ACS Style

Xu, W.; Song, B.; Bhadury, P.; Song, Y.; Hu, D. Synthesis and Crystal Structure of Novel Sulfone Derivatives Containing 1,2,4-Triazole Moieties. Molecules 2010, 15, 766-779.

AMA Style

Xu W, Song B, Bhadury P, Song Y, Hu D. Synthesis and Crystal Structure of Novel Sulfone Derivatives Containing 1,2,4-Triazole Moieties. Molecules. 2010; 15(2):766-779.

Chicago/Turabian Style

Xu, Weiming; Song, Baoan; Bhadury, Pinaki; Song, Yang; Hu, Deyu. 2010. "Synthesis and Crystal Structure of Novel Sulfone Derivatives Containing 1,2,4-Triazole Moieties." Molecules 15, no. 2: 766-779.

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