Next Article in Journal
Antioxidant Activities of Total Phenols of Prunella vulgaris L. in Vitro and in Tumor-bearing Mice
Previous Article in Journal
Experimental Models for Assaying Microvascular Endothelial Cell Pathophysiology in Stroke
Molecules 2010, 15(12), 9135-9144; doi:10.3390/molecules15129135
Article

Unexplored Nucleophilic Ring Opening of Aziridines

1,2
, 1,2
, 1,2,*  and 2
Received: 24 November 2010; in revised form: 1 December 2010 / Accepted: 6 December 2010 / Published: 10 December 2010
Download PDF [279 KB, uploaded 18 June 2014]
Abstract: The reactivity of dianions of carboxylic acids towards aziridines has been studied. Although, a similar reactivity to that of enolates from ketones, esters or amides has been observed, the method directly yields g-aminoacids in one step. The method is complementary of previous results of enenediolate reactivity with other electrophiles. A comparative study with the reactivity of this enediolates with epoxides is included.
Keywords: enediolate; regioselectivity; diastereoselectivity; aziridines; g-aminoacids enediolate; regioselectivity; diastereoselectivity; aziridines; g-aminoacids
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Costero, A.M.; Gil, S.; Parra, M.; Rodríguez, P. Unexplored Nucleophilic Ring Opening of Aziridines. Molecules 2010, 15, 9135-9144.

AMA Style

Costero AM, Gil S, Parra M, Rodríguez P. Unexplored Nucleophilic Ring Opening of Aziridines. Molecules. 2010; 15(12):9135-9144.

Chicago/Turabian Style

Costero, Ana María; Gil, Salvador; Parra, Margarita; Rodríguez, Pablo. 2010. "Unexplored Nucleophilic Ring Opening of Aziridines." Molecules 15, no. 12: 9135-9144.


Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert