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Molecules 2010, 15(12), 8593-8601; doi:10.3390/molecules15128593
Article

Synthesis of Benzofuran Derivatives via Rearrangement and Their Inhibitory Activity on Acetylcholinesterase

1, 2, 1, 2 and 1,*
1 Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China 2 Jiangsu Center for Drug Screening, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China
* Author to whom correspondence should be addressed.
Received: 15 September 2010 / Revised: 18 November 2010 / Accepted: 24 November 2010 / Published: 29 November 2010
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Abstract

During a synthesis of coumarins to obtain new candidates for treating Alzheimer’s Disease (AD), an unusual rearrangement of a benzopyran group to a benzofuran group occurred, offering a novel synthesis pathway of these benzofuran derivatives. The possible mechanism of the novel rearrangement was also discussed. All of the benzofuran derivatives have weak anti-AChE activities compared with the reference compound, donepezil.
Keywords: coumarin; benzofuran; rearrangement; anti-AChE coumarin; benzofuran; rearrangement; anti-AChE
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Zhou, X.; Li, M.; Wang, X.-B.; Wang, T.; Kong, L.-Y. Synthesis of Benzofuran Derivatives via Rearrangement and Their Inhibitory Activity on Acetylcholinesterase. Molecules 2010, 15, 8593-8601.

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