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Molecules 2010, 15(12), 8593-8601; doi:10.3390/molecules15128593
Article

Synthesis of Benzofuran Derivatives via Rearrangement and Their Inhibitory Activity on Acetylcholinesterase

1, 2, 1, 2 and 1,*
Received: 15 September 2010; in revised form: 18 November 2010 / Accepted: 24 November 2010 / Published: 29 November 2010
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Abstract: During a synthesis of coumarins to obtain new candidates for treating Alzheimer’s Disease (AD), an unusual rearrangement of a benzopyran group to a benzofuran group occurred, offering a novel synthesis pathway of these benzofuran derivatives. The possible mechanism of the novel rearrangement was also discussed. All of the benzofuran derivatives have weak anti-AChE activities compared with the reference compound, donepezil.
Keywords: coumarin; benzofuran; rearrangement; anti-AChE coumarin; benzofuran; rearrangement; anti-AChE
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zhou, X.; Li, M.; Wang, X.-B.; Wang, T.; Kong, L.-Y. Synthesis of Benzofuran Derivatives via Rearrangement and Their Inhibitory Activity on Acetylcholinesterase. Molecules 2010, 15, 8593-8601.

AMA Style

Zhou X, Li M, Wang X-B, Wang T, Kong L-Y. Synthesis of Benzofuran Derivatives via Rearrangement and Their Inhibitory Activity on Acetylcholinesterase. Molecules. 2010; 15(12):8593-8601.

Chicago/Turabian Style

Zhou, Xiang; Li, Miao; Wang, Xiao-Bing; Wang, Tao; Kong, Ling-Yi. 2010. "Synthesis of Benzofuran Derivatives via Rearrangement and Their Inhibitory Activity on Acetylcholinesterase." Molecules 15, no. 12: 8593-8601.



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