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Molecules 2010, 15(11), 7884-7892; doi:10.3390/molecules15117884

Prooxidant/Antioxidant Ratio (ProAntidex) as a Better Index of Net Free Radical Scavenging Potential

1,* , 2
1 Department of Physiology, Faculty of Medicine, 50603, University of Malaya, Kuala Lumpur, Malaysia 2 School of Medicine and Health Sciences, Monash University Sunway Campus, 46150, Petaling Jaya, Malaysia
* Author to whom correspondence should be addressed.
Received: 6 September 2010 / Revised: 1 October 2010 / Accepted: 19 October 2010 / Published: 3 November 2010
(This article belongs to the Special Issue Phenolics and Polyphenolics)
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The antioxidant activity of several Malaysian plant extracts was analyzed simultaneously with their pro-oxidant capacity. This ratio represents an index (ProAntidex) of the net free radical scavenging ability of whole plant extracts. We observed that ethanolic extracts of Nephelium lappaceum peel, Fragaria x ananassa leaf, Lawsonia inermis leaf, Syzygium aqueum leaf and grape seed had a lower Pro-Antidex than the commercially available Emblica™ extract which is an antioxidant agent with very low pro-oxidant activity. Among the aqueous extracts, Lawsonia inermis leaf, Nephelium mutobile leaf and grape seed had lower pro-oxidant activity compared to the Emblica™ extract. Among these extracts, aqueous extract of Nephelium mutobile leaf had a very low index of 0.05 compared to 0.69 for Emblica™. Most of the extracts had a far lower ProAntidex compared to the Vitamin C. The index enables us to identify extracts with high net free radical scavenging activity potential. The ProAntidex is beneficial as a screening parameter to the food industries and healthcare.
Keywords: pro-oxidant; DPPH; reducing power; antioxidants; EmblicaTM pro-oxidant; DPPH; reducing power; antioxidants; EmblicaTM
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Ling, L.T.; Palanisamy, U.D.; Cheng, H.M. Prooxidant/Antioxidant Ratio (ProAntidex) as a Better Index of Net Free Radical Scavenging Potential. Molecules 2010, 15, 7884-7892.

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