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Molecules 2010, 15(10), 7472-7481; doi:10.3390/molecules15107472

Synthesis of Novel 1-[(2,6-Dichloro-4-trifluoromethyl)phenyl]-3-aryl-1H-pyrazole-4-carbaldehydes

1,* , 1
1 College of Pharmaceutical and Chemical Engineering, Taizhou University, Linhai 317000, China 2 Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China 3 Ningbo Institute of Material Technology and Engineering, Chinese Academy of Sciences, Ningbo 315211, China
* Authors to whom correspondence should be addressed.
Received: 7 September 2010 / Revised: 29 September 2010 / Accepted: 2 October 2010 / Published: 25 October 2010
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A series of novel 1-[(2,6-dichloro-4-trifluoromethyl)phenyl]-3-aryl-1H-pyrazole-4-carbaldehydes 6a-i were synthesized using the Vilsmeier-Haack reagent. The structures of all the title compounds have been confirmed by elemental analysis, 1H-NMR and 13C-NMR and in addition, the structure of intermediate 5b was investigated by X-ray crystallography.
Keywords: Vilsmeier-Haack reagent; phenylhydrazine; phenylhydrazone; 1H-pyrazole-4-carbaldehyde Vilsmeier-Haack reagent; phenylhydrazine; phenylhydrazone; 1H-pyrazole-4-carbaldehyde
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Hu, H.; Ge, C.; Ding, L.; Zhang, A. Synthesis of Novel 1-[(2,6-Dichloro-4-trifluoromethyl)phenyl]-3-aryl-1H-pyrazole-4-carbaldehydes. Molecules 2010, 15, 7472-7481.

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