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Synthesis of Novel 1-[(2,6-Dichloro-4-trifluoromethyl)phenyl]-3-aryl-1H-pyrazole-4-carbaldehydes
College of Pharmaceutical and Chemical Engineering, Taizhou University, Linhai 317000, China
Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China
Ningbo Institute of Material Technology and Engineering, Chinese Academy of Sciences, Ningbo 315211, China
* Authors to whom correspondence should be addressed.
Received: 7 September 2010; in revised form: 29 September 2010 / Accepted: 2 October 2010 / Published: 25 October 2010
Abstract: A series of novel 1-[(2,6-dichloro-4-trifluoromethyl)phenyl]-3-aryl-1H-pyrazole-4-carbaldehydes 6a-i were synthesized using the Vilsmeier-Haack reagent. The structures of all the title compounds have been confirmed by elemental analysis, 1H-NMR and 13C-NMR and in addition, the structure of intermediate 5b was investigated by X-ray crystallography.
Keywords: Vilsmeier-Haack reagent; phenylhydrazine; phenylhydrazone; 1H-pyrazole-4-carbaldehyde
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MDPI and ACS Style
Hu, H.; Ge, C.; Ding, L.; Zhang, A. Synthesis of Novel 1-[(2,6-Dichloro-4-trifluoromethyl)phenyl]-3-aryl-1H-pyrazole-4-carbaldehydes. Molecules 2010, 15, 7472-7481.
Hu H, Ge C, Ding L, Zhang A. Synthesis of Novel 1-[(2,6-Dichloro-4-trifluoromethyl)phenyl]-3-aryl-1H-pyrazole-4-carbaldehydes. Molecules. 2010; 15(10):7472-7481.
Hu, Huanan; Ge, Changhua; Ding, Lisheng; Zhang, Anjiang. 2010. "Synthesis of Novel 1-[(2,6-Dichloro-4-trifluoromethyl)phenyl]-3-aryl-1H-pyrazole-4-carbaldehydes." Molecules 15, no. 10: 7472-7481.