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Molecules 2010, 15(10), 7423-7437; doi:10.3390/molecules15107423
Article

One-Pot Synthesis of 2,3,4-Triarylquinolines via Suzuki-Miyaura Cross-Coupling of 2-Aryl-4-chloro-3-iodoquinolines with Arylboronic Acids

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Received: 16 September 2010 / Revised: 12 October 2010 / Accepted: 18 October 2010 / Published: 22 October 2010
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Abstract

Palladium–catalyzed Suzuki cross-coupling of 2-aryl-4-chloro-3-iodoquinolines with excess arylboronic acids (2.5 equiv.) in the presence of tricyclohexylphosphine afforded the 2,3,4-triarylquinolines in one-pot operation. The incipient 2,3-diaryl-4-chloroquinolines were also prepared and transformed to the primary 4-amino-2,3-diarylquinolines and 2,3-diarylquinolin-4(1H)-ones.
Keywords: 2-aryl-4-chloro-3-iodoquinolines; Suzuki-Miyaura cross-coupling; 2,3-diaryl-4-chloroquinolines; 2,3,4-triarylquinolines 2-aryl-4-chloro-3-iodoquinolines; Suzuki-Miyaura cross-coupling; 2,3-diaryl-4-chloroquinolines; 2,3,4-triarylquinolines
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Mphahlele, M.J.; Mphahlele, M.M. One-Pot Synthesis of 2,3,4-Triarylquinolines via Suzuki-Miyaura Cross-Coupling of 2-Aryl-4-chloro-3-iodoquinolines with Arylboronic Acids. Molecules 2010, 15, 7423-7437.

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