Molecules 2010, 15(10), 7423-7437; doi:10.3390/molecules15107423
Article

One-Pot Synthesis of 2,3,4-Triarylquinolines via Suzuki-Miyaura Cross-Coupling of 2-Aryl-4-chloro-3-iodoquinolines with Arylboronic Acids

Malose Jack Mphahlele* email and Mamasegare Mabel Mphahlele
Department of Chemistry, College of Science, Engineering and Technology, University of South Africa, P.O. Box 392, Pretoria 0003, South Africa
* Author to whom correspondence should be addressed.
Received: 16 September 2010; in revised form: 12 October 2010 / Accepted: 18 October 2010 / Published: 22 October 2010
PDF Full-text Download PDF Full-Text [226 KB, uploaded 22 October 2010 17:00 CEST]
Abstract: Palladium–catalyzed Suzuki cross-coupling of 2-aryl-4-chloro-3-iodoquinolines with excess arylboronic acids (2.5 equiv.) in the presence of tricyclohexylphosphine afforded the 2,3,4-triarylquinolines in one-pot operation. The incipient 2,3-diaryl-4-chloroquinolines were also prepared and transformed to the primary 4-amino-2,3-diarylquinolines and 2,3-diarylquinolin-4(1H)-ones.
Keywords: 2-aryl-4-chloro-3-iodoquinolines; Suzuki-Miyaura cross-coupling; 2,3-diaryl-4-chloroquinolines; 2,3,4-triarylquinolines

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Mphahlele, M.J.; Mphahlele, M.M. One-Pot Synthesis of 2,3,4-Triarylquinolines via Suzuki-Miyaura Cross-Coupling of 2-Aryl-4-chloro-3-iodoquinolines with Arylboronic Acids. Molecules 2010, 15, 7423-7437.

AMA Style

Mphahlele MJ, Mphahlele MM. One-Pot Synthesis of 2,3,4-Triarylquinolines via Suzuki-Miyaura Cross-Coupling of 2-Aryl-4-chloro-3-iodoquinolines with Arylboronic Acids. Molecules. 2010; 15(10):7423-7437.

Chicago/Turabian Style

Mphahlele, Malose Jack; Mphahlele, Mamasegare Mabel. 2010. "One-Pot Synthesis of 2,3,4-Triarylquinolines via Suzuki-Miyaura Cross-Coupling of 2-Aryl-4-chloro-3-iodoquinolines with Arylboronic Acids." Molecules 15, no. 10: 7423-7437.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert