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Antibacterial Activity of Phytochemicals Isolated from Atractylodes japonica against Methicillin-Resistant Staphylococcus aureus
Jeonju Biomaterials Institute, Jeonju 561-360, Korea
Department of Laboratory Medicine, Veterans Hospital, Daejeon, 306-830, Korea
GL Sciences Inc, Tokyo, Japan
Department of Oral Microbiology, School of Dentistry and Biotechnology Institute, Wonkwang University, Iksan 570-749, Korea
* Author to whom correspondence should be addressed.
Received: 7 September 2010 / Accepted: 19 October 2010 / Published: 21 October 2010
Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) has been emerging worldwide as one of the most important problems in communities and hospitals. Therefore, new agents are needed to treat acute oral infections from MRSA. In this study, antibacterial compounds from the roots of Atractylodes japonica (A. japonica) were isolated and characterized. The compounds were isolated from the root extracts using HPLC-piloted activity-guided fractionations. Four A. japonica compounds were isolated and identified as atractylenolide III (1), atractylenolide I (2), diacetylatractylodiol [(6E,12E)-tetradeca-6,12-diene-8,10-diyne-1,3-diol diacetate, TDEYA, 3). and (6E,12E)-tetradecadiene-8,10-diyne-1,3-diol (TDEA, 4), which was obtained by hydrolysis of TDEYA. The minimum inhibitory concentrations (MICs) was determined in the setting of clinical MRSA isolates. Compound 4 showed anti-MRSA activity with a MIC value of 4-32 μg/mL. The overall results provide promising baseline information for the potential use of the extract of A. japonica as well as some of the isolated compounds in the treatment of bacterial infections.
Keywords: Atractylodes japonica; MRSA; MIC/MBC
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MDPI and ACS Style
Jeong, S.-I.; Kim, S.-Y.; Kim, S.-J.; Hwang, B.-S.; Kwon, T.-H.; Yu, K.-Y.; Hang, S.-H.; Suzuki, K.; Kim, K.-J. Antibacterial Activity of Phytochemicals Isolated from Atractylodes japonica against Methicillin-Resistant Staphylococcus aureus. Molecules 2010, 15, 7395-7402.
Jeong S-I, Kim S-Y, Kim S-J, Hwang B-S, Kwon T-H, Yu K-Y, Hang S-H, Suzuki K, Kim K-J. Antibacterial Activity of Phytochemicals Isolated from Atractylodes japonica against Methicillin-Resistant Staphylococcus aureus. Molecules. 2010; 15(10):7395-7402.
Jeong, Seung-Il; Kim, Seon-Young; Kim, Sang-Jun; Hwang, Byung-Soon; Kwon, Tae-Ho; Yu, Kang-Yeol; Hang, Seung-Ho; Suzuki, Koji; Kim, Kang-Ju. 2010. "Antibacterial Activity of Phytochemicals Isolated from Atractylodes japonica against Methicillin-Resistant Staphylococcus aureus." Molecules 15, no. 10: 7395-7402.