Molecules 2010, 15(10), 7395-7402; doi:10.3390/molecules15107395
Article

Antibacterial Activity of Phytochemicals Isolated from Atractylodes japonica against Methicillin-Resistant Staphylococcus aureus

1email, 1email, 1email, 1email, 1email, 1email, 2email, 3email and 4,* email
Received: 7 September 2010; Accepted: 19 October 2010 / Published: 21 October 2010
(This article belongs to the collection Bioactive Compounds)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) has been emerging worldwide as one of the most important problems in communities and hospitals. Therefore, new agents are needed to treat acute oral infections from MRSA. In this study, antibacterial compounds from the roots of Atractylodes japonica (A. japonica) were isolated and characterized. The compounds were isolated from the root extracts using HPLC-piloted activity-guided fractionations. Four A. japonica compounds were isolated and identified as atractylenolide III (1), atractylenolide I (2), diacetylatractylodiol [(6E,12E)-tetradeca-6,12-diene-8,10-diyne-1,3-diol diacetate, TDEYA, 3). and (6E,12E)-tetradecadiene-8,10-diyne-1,3-diol (TDEA, 4), which was obtained by hydrolysis of TDEYA. The minimum inhibitory concentrations (MICs) was determined in the setting of clinical MRSA isolates. Compound 4 showed anti-MRSA activity with a MIC value of 4-32 μg/mL. The overall results provide promising baseline information for the potential use of the extract of A. japonica as well as some of the isolated compounds in the treatment of bacterial infections.
Keywords: Atractylodes japonica; MRSA; MIC/MBC
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MDPI and ACS Style

Jeong, S.-I.; Kim, S.-Y.; Kim, S.-J.; Hwang, B.-S.; Kwon, T.-H.; Yu, K.-Y.; Hang, S.-H.; Suzuki, K.; Kim, K.-J. Antibacterial Activity of Phytochemicals Isolated from Atractylodes japonica against Methicillin-Resistant Staphylococcus aureus. Molecules 2010, 15, 7395-7402.

AMA Style

Jeong S-I, Kim S-Y, Kim S-J, Hwang B-S, Kwon T-H, Yu K-Y, Hang S-H, Suzuki K, Kim K-J. Antibacterial Activity of Phytochemicals Isolated from Atractylodes japonica against Methicillin-Resistant Staphylococcus aureus. Molecules. 2010; 15(10):7395-7402.

Chicago/Turabian Style

Jeong, Seung-Il; Kim, Seon-Young; Kim, Sang-Jun; Hwang, Byung-Soon; Kwon, Tae-Ho; Yu, Kang-Yeol; Hang, Seung-Ho; Suzuki, Koji; Kim, Kang-Ju. 2010. "Antibacterial Activity of Phytochemicals Isolated from Atractylodes japonica against Methicillin-Resistant Staphylococcus aureus." Molecules 15, no. 10: 7395-7402.

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