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Molecules 2010, 15(10), 7075-7082; doi:10.3390/molecules15107075

The Fungicidal Terpenoids and Essential Oil from Litsea cubeba in Tibet

Department of Applied Chemistry, China Agricultural University, Beijing 100193, China
Department of Chemistry, College of Sciences, Tibet University, Lhasa 850000, China
Institute of Plant Protection, China Academy of Agricultural Sciences, Beijing 100193, China
Author to whom correspondence should be addressed.
Received: 7 September 2010 / Revised: 25 September 2010 / Accepted: 11 October 2010 / Published: 13 October 2010
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A new C9 monoterpenoid acid (litseacubebic acid, 1) and a known monoterpene lactone (6R)-3,7-dimethyl-7-hydroxy-2-octen-6-olide (2), along with three known compounds – vanillic acid (3), trans-3,4,5-trimethoxylcinnamyl alcohol (4), and oxonantenine (5) – were isolated with bioassay-guided purification from the fruit extract of Litsea cubeba collected in Tibet. The structure of 1 was elucidated by MS, 1H-NMR, 13C-NMR, COSY, HSQC, HMBC, NOE spectral data as 2,6-dimethyl-6-hydroxy-2E,4E-hepta-2,4-diene acid. Additionally 33 compounds were identified from the essential oil of L. cubeba. The preliminary bioassay results showed that 1 and 2 have good fungicidal activities against Sclerotinia sclerotiorum, Thanatephorus cucumeris, Pseudocer-cospora musae and Colletotrichum gloeosporioides at the concentration of 588 and 272 μM, and the essential oil has good fungicidal activities against T. cucumeris and S. sclerotiorum, with IC50 values of 115.58 and 151.25 μg/mL, repectively.
Keywords: Litsea cubeba; Lauraceae; (6R)-3,7-dimethyl-7-hydroxy-2-octen-6-olide; litseacubebic acid; essential oil; fungicidal activity Litsea cubeba; Lauraceae; (6R)-3,7-dimethyl-7-hydroxy-2-octen-6-olide; litseacubebic acid; essential oil; fungicidal activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Yang, Y.; Jiang, J.; Qimei, L.; Yan, X.; Zhao, J.; Yuan, H.; Qin, Z.; Wang, M. The Fungicidal Terpenoids and Essential Oil from Litsea cubeba in Tibet. Molecules 2010, 15, 7075-7082.

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