Molecules 2010, 15(10), 7016-7034; doi:10.3390/molecules15107016

Synthesis and Reactivity of [1,2,4]Triazolo-annelated Quinazolines

Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
Received: 25 September 2010; in revised form: 29 September 2010 / Accepted: 8 October 2010 / Published: 12 October 2010
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Abstract: This paper reports the synthesis of phenyl-substituted 2-alkoxy(methylsulfanyl)-1,2,4-triazolo[1,5-a]quinazolines starting from N-cyanoimidocarbonates and substituted hydrazinobenzoic acids as building blocks. Thionation or chlorination of the inherent lactam moiety in the target compounds followed by treatment with multifunctional nucleophiles provided access to a variety of derivatives.
Keywords: triazolo[1,5-a]quinazolines; thionation; alkylation; chlorination; tetracyclic systems


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MDPI and ACS Style

Al-Salahi, R.A. Synthesis and Reactivity of [1,2,4]Triazolo-annelated Quinazolines. Molecules 2010, 15, 7016-7034.

AMA Style

Al-Salahi RA. Synthesis and Reactivity of [1,2,4]Triazolo-annelated Quinazolines. Molecules. 2010; 15(10):7016-7034.

Chicago/Turabian Style

Al-Salahi, Rashad A. 2010. "Synthesis and Reactivity of [1,2,4]Triazolo-annelated Quinazolines." Molecules 15, no. 10: 7016-7034.

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