Open AccessThis article is
- freely available
Synthesis and Anti-Bacterial Activities of Some Novel Schiff Bases Derived from Aminophenazone
Chemistry Department, Faculty of Science, King Abdul Aziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia
The Center of Excellence for Advanced Materials, King Abdul Aziz University, Jeddah 21589, P.O. Box 80203, Saudi Arabia
* Author to whom correspondence should be addressed.
Received: 20 July 2010; in revised form: 16 August 2010 / Accepted: 18 August 2010 / Published: 8 October 2010
Abstract: A series of 1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one-containing Schiff bases were synthesized, characterized and screened for their antibacterial activities. The structures of the synthesized compounds were established by spectroscopic (FT-IR, 1H-NMR, 13C-NMR, MS) and elemental analyses. The anti-bacterial activities (with MIC values) of compounds were evaluated. The anti-bacterial screening results reveal that among the six compounds screened, four compounds showed moderate to good anti-bacterial activity. Among the tested compounds, the most effective compounds against four bacterial strains, viz. Escherichia coli, Staphylococcus aureus, Salmonella typhimurium and Streptococcus pyogenes, are [(2-Chlorobenzylidene)amino]-1,5-dimethyl-2-phenyl-1,2-dihydropyrazol-3-one (4) and [(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylimino)methyl]benzonitrile (5) with MIC values of 6.25 μg/mL.
Keywords: Schiff bases; aminophenazone; antibacterial activity; ciprofloxacin
Article StatisticsClick here to load and display the download statistics.
Notes: Multiple requests from the same IP address are counted as one view.
Cite This Article
MDPI and ACS Style
Asiri, A.M.; Khan, S.A. Synthesis and Anti-Bacterial Activities of Some Novel Schiff Bases Derived from Aminophenazone. Molecules 2010, 15, 6850-6858.
Asiri AM, Khan SA. Synthesis and Anti-Bacterial Activities of Some Novel Schiff Bases Derived from Aminophenazone. Molecules. 2010; 15(10):6850-6858.
Asiri, Abdullah M.; Khan, Salman A. 2010. "Synthesis and Anti-Bacterial Activities of Some Novel Schiff Bases Derived from Aminophenazone." Molecules 15, no. 10: 6850-6858.