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Molecules 2010, 15(1), 399-406; doi:10.3390/molecules15010399
Article

Isolation, Synthesis and Structures of Ginsenoside Derivatives and Their Anti-Tumor Bioactivity

1,†, 1,†
,
2,* , 1,3, 1, 1,*  and 3
1 College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China 2 Department of Pharmaceutical Science, Henan College of Traditional Chinese Medicine, Zhengzhou 450008, China 3 Norman Bethune College of Medicine, Jilin University, Changchun, 130000, China These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 4 December 2009 / Revised: 8 January 2010 / Accepted: 11 January 2010 / Published: 19 January 2010
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Abstract

Protopanaxatriol saponins obtained with AB-8 macroporous resin mainly consisted of ginsenosides Rg1 and Re. A novel mono-ester of ginsenoside-Rh1 (ginsenoside-ORh1) was synthesized through further enzymatic hydrolysis and octanoyl chloride modifications. A 53% yield was obtained by a facile synthetic method. The structures were identified on the basis of 1D-NMR and 2D-NMR, as well as ESI-TOF-MS mass spectroscopic analyses. The isolated and synthetic compounds were applied in an anti-tumor bioassay, in which ginsenoside ORh1 showed moderate effects on Murine H22 Hepatoma Cells.
Keywords: isolation; synthesis; ginsenoside-ORh1 isolation; synthesis; ginsenoside-ORh1
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Han, M.; Hou, J.-G.; Dong, C.-M.; Li, W.; Yu, H.-L.; Zheng, Y.-N.; Chen, L. Isolation, Synthesis and Structures of Ginsenoside Derivatives and Their Anti-Tumor Bioactivity. Molecules 2010, 15, 399-406.

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