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Molecules 2010, 15(1), 399-406; doi:10.3390/molecules15010399

Isolation, Synthesis and Structures of Ginsenoside Derivatives and Their Anti-Tumor Bioactivity

1,†, 1,†
2,* , 1,3, 1, 1,*  and 3
1 College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China 2 Department of Pharmaceutical Science, Henan College of Traditional Chinese Medicine, Zhengzhou 450008, China 3 Norman Bethune College of Medicine, Jilin University, Changchun, 130000, China These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 4 December 2009 / Revised: 8 January 2010 / Accepted: 11 January 2010 / Published: 19 January 2010
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Protopanaxatriol saponins obtained with AB-8 macroporous resin mainly consisted of ginsenosides Rg1 and Re. A novel mono-ester of ginsenoside-Rh1 (ginsenoside-ORh1) was synthesized through further enzymatic hydrolysis and octanoyl chloride modifications. A 53% yield was obtained by a facile synthetic method. The structures were identified on the basis of 1D-NMR and 2D-NMR, as well as ESI-TOF-MS mass spectroscopic analyses. The isolated and synthetic compounds were applied in an anti-tumor bioassay, in which ginsenoside ORh1 showed moderate effects on Murine H22 Hepatoma Cells.
Keywords: isolation; synthesis; ginsenoside-ORh1 isolation; synthesis; ginsenoside-ORh1
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Han, M.; Hou, J.-G.; Dong, C.-M.; Li, W.; Yu, H.-L.; Zheng, Y.-N.; Chen, L. Isolation, Synthesis and Structures of Ginsenoside Derivatives and Their Anti-Tumor Bioactivity. Molecules 2010, 15, 399-406.

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