Isolation, Synthesis and Structures of Ginsenoside Derivatives and Their Anti-Tumor Bioactivity

doi:10.3390/molecules15010399

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Molecules 2010, 15(1), 399-406; doi:10.3390/molecules15010399

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Isolation, Synthesis and Structures of Ginsenoside Derivatives and Their Anti-Tumor Bioactivity

Mei Han^1,†, Jin-Gang Hou^1,†, Cheng-Ming Dong^2,* , Wei Li^1,3, Hao-Lun Yu¹, Yi-Nan Zheng^1,* and Li Chen³

¹ College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China ² Department of Pharmaceutical Science, Henan College of Traditional Chinese Medicine, Zhengzhou 450008, China ³ Norman Bethune College of Medicine, Jilin University, Changchun, 130000, China ^† These authors contributed equally to this work.

* Authors to whom correspondence should be addressed.

Received: 4 December 2009; in revised form: 8 January 2010 / Accepted: 11 January 2010 / Published: 19 January 2010

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Abstract: Protopanaxatriol saponins obtained with AB-8 macroporous resin mainly consisted of ginsenosides Rg₁ and Re. A novel mono-ester of ginsenoside-Rh₁ (ginsenoside-ORh₁) was synthesized through further enzymatic hydrolysis and octanoyl chloride modifications. A 53% yield was obtained by a facile synthetic method. The structures were identified on the basis of 1D-NMR and 2D-NMR, as well as ESI-TOF-MS mass spectroscopic analyses. The isolated and synthetic compounds were applied in an anti-tumor bioassay, in which ginsenoside ORh₁ showed moderate effects on Murine H22 Hepatoma Cells.

Keywords: isolation; synthesis; ginsenoside-ORh₁

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MDPI and ACS Style

Han, M.; Hou, J.-G.; Dong, C.-M.; Li, W.; Yu, H.-L.; Zheng, Y.-N.; Chen, L. Isolation, Synthesis and Structures of Ginsenoside Derivatives and Their Anti-Tumor Bioactivity. Molecules 2010, 15, 399-406.

AMA Style

Han M, Hou J-G, Dong C-M, Li W, Yu H-L, Zheng Y-N, Chen L. Isolation, Synthesis and Structures of Ginsenoside Derivatives and Their Anti-Tumor Bioactivity. Molecules. 2010; 15(1):399-406.

Chicago/Turabian Style

Han, Mei; Hou, Jin-Gang; Dong, Cheng-Ming; Li, Wei; Yu, Hao-Lun; Zheng, Yi-Nan; Chen, Li. 2010. "Isolation, Synthesis and Structures of Ginsenoside Derivatives and Their Anti-Tumor Bioactivity." Molecules 15, no. 1: 399-406.

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