Molecules 2010, 15(1), 270-279; doi:10.3390/molecules15010270
Article

Synthesis and Vasorelaxant and Platelet Antiaggregatory Activities of a New Series of 6-Halo-3-phenylcoumarins

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Received: 4 December 2009; in revised form: 21 December 2009 / Accepted: 23 December 2009 / Published: 12 January 2010
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A series of 6-halo-3-hydroxyphenylcoumarins (resveratrol-coumarins hybrid derivatives) was synthesized in good yields by a Perkin reaction followed by hydrolysis. The new compounds were evaluated for their vasorelaxant activity in intact rat aorta rings pre-contracted with phenylephrine (PE), as well as for their inhibitory effects on platelet aggregation induced by thrombin in washed human platelets. These compounds concentration-dependently relaxed vascular smooth muscle and some of them showed a platelet antiaggregatory activity that was up to thirty times higher than that shown by trans-resveratrol and some other previously synthesized derivatives.
Keywords: resveratrol; coumarin; vasorelaxant; platelet antiaggregatory activity
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MDPI and ACS Style

Quezada, E.; Delogu, G.; Picciau, C.; Santana, L.; Podda, G.; Borges, F.; García-Morales, V.; Viña, D.; Orallo, F. Synthesis and Vasorelaxant and Platelet Antiaggregatory Activities of a New Series of 6-Halo-3-phenylcoumarins. Molecules 2010, 15, 270-279.

AMA Style

Quezada E, Delogu G, Picciau C, Santana L, Podda G, Borges F, García-Morales V, Viña D, Orallo F. Synthesis and Vasorelaxant and Platelet Antiaggregatory Activities of a New Series of 6-Halo-3-phenylcoumarins. Molecules. 2010; 15(1):270-279.

Chicago/Turabian Style

Quezada, Elías; Delogu, Giovanna; Picciau, Carmen; Santana, Lourdes; Podda, Gianni; Borges, Fernanda; García-Morales, Verónica; Viña, Dolores; Orallo, Francisco. 2010. "Synthesis and Vasorelaxant and Platelet Antiaggregatory Activities of a New Series of 6-Halo-3-phenylcoumarins." Molecules 15, no. 1: 270-279.

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