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Addendum published on 22 March 2010, see Molecules 2010, 15(3), 1985-1986.

Molecules 2010, 15(1), 128-137; doi:10.3390/molecules15010128
Article

Synthesis of New Imidazolidin-2,4-dione and 2-Thioxoimidazolidin-4-ones via C-Phenylglycine Derivatives

1,2, 1, 1, 1, 1, 3, 3 and 1,3,*
1 Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, João Pessoa - PB, CEP 58.051-970, Brazil 2 Centro de Educação e Saúde, Unidade Acadêmica de Saúde, Universidade Federal de Campina Grande, Cuité - PB, CEP 58.175-000, Brazil 3 Departamento de Química, Universidade Federal da Paraíba, Campus I, João Pessoa - PB, CEP 58059-900, Brazil
* Author to whom correspondence should be addressed.
Received: 13 October 2009 / Revised: 1 December 2009 / Accepted: 2 December 2009 / Published: 30 December 2009
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Abstract

Hydantoins and their derivatives constitute a group of pharmaceutical compounds with anticonvulsant and antiarrhythmic properties, and are also used against diabetes. N-3 and C-5 substituted imidazolidines are examples of such products. As such, we have developed a synthesis of 2,4-dione and 2-thioxo-4-one imidazolidinic derivatives by reaction of amino acids with C-phenylglycine, phenyl isocyanate and phenyl isothiocyanate. Four amino-derivatives IG(1-4) and eight imidazolidinic derivatives, IM(1-8), were obtained in yields of 70–74%. The mass, infrared, 1H and 13C-NMR spectra of representative products are discussed.
Keywords: hydantoins; C-phenylglycine; imidazolidines; 2-thioxoimidazolidine-4-ones hydantoins; C-phenylglycine; imidazolidines; 2-thioxoimidazolidine-4-ones
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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De Sousa Luis, J.A.; Barbosa Filho, J.M.; Freitas Lira, B.; Almeida Medeiros, I.; Soares Lima de Morais, L.C.; Dos Santos, A.F.; Soares de Oliveira, C.; De Athayde-Filho, P.F. Synthesis of New Imidazolidin-2,4-dione and 2-Thioxoimidazolidin-4-ones via C-Phenylglycine Derivatives. Molecules 2010, 15, 128-137.

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