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An addendum was published on 22 March 2010, see Molecules 2010, 15(3), 1985-1986.

Molecules 2010, 15(1), 128-137; doi:10.3390/molecules15010128
Article

Synthesis of New Imidazolidin-2,4-dione and 2-Thioxoimidazolidin-4-ones via C-Phenylglycine Derivatives

1,2, 1, 1, 1, 1, 3, 3 and 1,3,*
Received: 13 October 2009; in revised form: 1 December 2009 / Accepted: 2 December 2009 / Published: 30 December 2009
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Abstract: Hydantoins and their derivatives constitute a group of pharmaceutical compounds with anticonvulsant and antiarrhythmic properties, and are also used against diabetes. N-3 and C-5 substituted imidazolidines are examples of such products. As such, we have developed a synthesis of 2,4-dione and 2-thioxo-4-one imidazolidinic derivatives by reaction of amino acids with C-phenylglycine, phenyl isocyanate and phenyl isothiocyanate. Four amino-derivatives IG(1-4) and eight imidazolidinic derivatives, IM(1-8), were obtained in yields of 70–74%. The mass, infrared, 1H and 13C-NMR spectra of representative products are discussed.
Keywords: hydantoins; C-phenylglycine; imidazolidines; 2-thioxoimidazolidine-4-ones hydantoins; C-phenylglycine; imidazolidines; 2-thioxoimidazolidine-4-ones
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

De Sousa Luis, J.A.; Barbosa Filho, J.M.; Freitas Lira, B.; Almeida Medeiros, I.; Soares Lima de Morais, L.C.; Dos Santos, A.F.; Soares de Oliveira, C.; De Athayde-Filho, P.F. Synthesis of New Imidazolidin-2,4-dione and 2-Thioxoimidazolidin-4-ones via C-Phenylglycine Derivatives. Molecules 2010, 15, 128-137.

AMA Style

De Sousa Luis JA, Barbosa Filho JM, Freitas Lira B, Almeida Medeiros I, Soares Lima de Morais LC, Dos Santos AF, Soares de Oliveira C, De Athayde-Filho PF. Synthesis of New Imidazolidin-2,4-dione and 2-Thioxoimidazolidin-4-ones via C-Phenylglycine Derivatives. Molecules. 2010; 15(1):128-137.

Chicago/Turabian Style

De Sousa Luis, José Alixandre; Barbosa Filho, José Maria; Freitas Lira, Bruno; Almeida Medeiros, Isac; Soares Lima de Morais, Liana Clébia; Dos Santos, Alexsandro Fernandes; Soares de Oliveira, Cledualdo; De Athayde-Filho, Petrônio Filgueiras. 2010. "Synthesis of New Imidazolidin-2,4-dione and 2-Thioxoimidazolidin-4-ones via C-Phenylglycine Derivatives." Molecules 15, no. 1: 128-137.


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