Next Article in Journal
The Anti-HIV Actions of 7- and 10-Substituted Camptothecins
Previous Article in Journal
JNK Contributes to Hif-1α Regulation in Hypoxic Neurons
Addendum published on 22 March 2010, see Molecules 2010, 15(3), 1985-1986.

Molecules 2010, 15(1), 128-137; doi:10.3390/molecules15010128

Synthesis of New Imidazolidin-2,4-dione and 2-Thioxoimidazolidin-4-ones via C-Phenylglycine Derivatives

1,2, 1, 1, 1, 1, 3, 3 and 1,3,*
1 Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, João Pessoa - PB, CEP 58.051-970, Brazil 2 Centro de Educação e Saúde, Unidade Acadêmica de Saúde, Universidade Federal de Campina Grande, Cuité - PB, CEP 58.175-000, Brazil 3 Departamento de Química, Universidade Federal da Paraíba, Campus I, João Pessoa - PB, CEP 58059-900, Brazil
* Author to whom correspondence should be addressed.
Received: 13 October 2009 / Revised: 1 December 2009 / Accepted: 2 December 2009 / Published: 30 December 2009
Download PDF [223 KB, uploaded 18 June 2014]


Hydantoins and their derivatives constitute a group of pharmaceutical compounds with anticonvulsant and antiarrhythmic properties, and are also used against diabetes. N-3 and C-5 substituted imidazolidines are examples of such products. As such, we have developed a synthesis of 2,4-dione and 2-thioxo-4-one imidazolidinic derivatives by reaction of amino acids with C-phenylglycine, phenyl isocyanate and phenyl isothiocyanate. Four amino-derivatives IG(1-4) and eight imidazolidinic derivatives, IM(1-8), were obtained in yields of 70–74%. The mass, infrared, 1H and 13C-NMR spectra of representative products are discussed.
Keywords: hydantoins; C-phenylglycine; imidazolidines; 2-thioxoimidazolidine-4-ones hydantoins; C-phenylglycine; imidazolidines; 2-thioxoimidazolidine-4-ones
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

De Sousa Luis, J.A.; Barbosa Filho, J.M.; Freitas Lira, B.; Almeida Medeiros, I.; Soares Lima de Morais, L.C.; Dos Santos, A.F.; Soares de Oliveira, C.; De Athayde-Filho, P.F. Synthesis of New Imidazolidin-2,4-dione and 2-Thioxoimidazolidin-4-ones via C-Phenylglycine Derivatives. Molecules 2010, 15, 128-137.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert