Next Article in Journal
Ruthenium(III) Chloride Catalyzed Acylation of Alcohols, Phenols, and Thiols in Room Temperature Ionic Liquids
Next Article in Special Issue
Chemistry of the M (M=Fe, Ca, Ba)-Se-H2O Systems at 25 °C
Previous Article in Journal
Publisher's Note - Pagination Error, Molecules 2009, 14(3)
Previous Article in Special Issue
Cesium Carbonate-Catalyzed α-Phenylchalcogenation of Carbonyl Compounds with Diphenyl Dichalcogenide
Molecules 2009, 14(9), 3509-3527; doi:10.3390/molecules14093509

Mouse Models Targeting Selenocysteine tRNA Expression for Elucidating the Role of Selenoproteins in Health and Development

1,* , 1
Received: 17 August 2009 / Revised: 3 September 2009 / Accepted: 7 September 2009 / Published: 10 September 2009
(This article belongs to the Special Issue Selenium and Tellurium Chemistry)
Download PDF [328 KB, uploaded 18 June 2014]


Selenium (Se) deficiency has been known for many years to be associated with disease, impaired growth and a variety of other metabolic disorders in mammals. Only recently has the major role that Se-containing proteins, designated selenoproteins, play in many aspects of health and development begun to emerge. Se is incorporated into protein by way of the Se-containing amino acid, selenocysteine (Sec). The synthesis of selenoproteins is dependent on Sec tRNA for insertion of Sec, the 21st amino acid in the genetic code, into protein. We have taken advantage of this dependency to modulate the expression of Sec tRNA that in turn modulates the expression of selenoproteins by generating transgenic, conditional knockout, transgenic/standard knockout and transgenic/conditional knockout mouse models, all of which involve the Sec tRNA gene, to elucidate the intracellular roles of this protein class.
Keywords: mouse models; selenium; selenocysteine tRNA; selenoproteins mouse models; selenium; selenocysteine tRNA; selenoproteins
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Carlson, B.A.; Yoo, M.-H.; Tsuji, P.A.; Gladyshev, V.N.; Hatfield, D.L. Mouse Models Targeting Selenocysteine tRNA Expression for Elucidating the Role of Selenoproteins in Health and Development. Molecules 2009, 14, 3509-3527.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert