Molecules 2009, 14(9), 3425-3435; doi:10.3390/molecules14093425
Article

Microbial Growth and Quorum Sensing Antagonist Activities of Herbal Plants Extracts

email and * email
Received: 2 July 2009; in revised form: 26 July 2009 / Accepted: 5 August 2009 / Published: 3 September 2009
Download PDF [74 KB, uploaded 18 June 2014]
Abstract: Antimicrobial and antiquorum sensing (AQS) activities of fourteen ethanolic extracts of different parts of eight plants were screened against four Gram-positive, five Gram-negative bacteria and four fungi. Depending on the plant part extract used and the test microorganism, variable activities were recorded at 3 mg per disc. Among the Grampositive bacteria tested, for example, activities of Laurus nobilis bark extract ranged between a 9.5 mm inhibition zone against Bacillus subtilis up to a 25 mm one against methicillin resistant Staphylococcus aureus. Staphylococcus aureus and Aspergillus fumigatus were the most susceptible among bacteria and fungi tested towards other plant parts. Of interest is the tangible antifungal activity of a Tecoma capensis flower extract, which is reported for the first time. However, minimum inhibitory concentrations (MIC's) for both bacteria and fungi were relatively high (0.5-3.0 mg). As for antiquorum sensing activity against Chromobacterium violaceum, superior activity (>17 mm QS inhibition) was associated with Sonchus oleraceus and Laurus nobilis extracts and weak to good activity (8-17 mm) was recorded for other plants. In conclusion, results indicate the potential of these plant extracts in treating microbial infections through cell growth inhibition or quorum sensing antagonism, which is reported for the first time, thus validating their medicinal use.
Keywords: antimicrobial agents; antiquorum sensing; herbal extracts
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Al-Hussaini, R.; Mahasneh, A.M. Microbial Growth and Quorum Sensing Antagonist Activities of Herbal Plants Extracts. Molecules 2009, 14, 3425-3435.

AMA Style

Al-Hussaini R, Mahasneh AM. Microbial Growth and Quorum Sensing Antagonist Activities of Herbal Plants Extracts. Molecules. 2009; 14(9):3425-3435.

Chicago/Turabian Style

Al-Hussaini, Reema; Mahasneh, Adel M. 2009. "Microbial Growth and Quorum Sensing Antagonist Activities of Herbal Plants Extracts." Molecules 14, no. 9: 3425-3435.


Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert