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Molecules 2009, 14(9), 3425-3435; doi:10.3390/molecules14093425

Microbial Growth and Quorum Sensing Antagonist Activities of Herbal Plants Extracts

Department of Biological Sciences, Faculty of Sciences, University of Jordan, Amman 11942, Jordan
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Received: 2 July 2009 / Revised: 26 July 2009 / Accepted: 5 August 2009 / Published: 3 September 2009
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Abstract

Antimicrobial and antiquorum sensing (AQS) activities of fourteen ethanolic extracts of different parts of eight plants were screened against four Gram-positive, five Gram-negative bacteria and four fungi. Depending on the plant part extract used and the test microorganism, variable activities were recorded at 3 mg per disc. Among the Grampositive bacteria tested, for example, activities of Laurus nobilis bark extract ranged between a 9.5 mm inhibition zone against Bacillus subtilis up to a 25 mm one against methicillin resistant Staphylococcus aureus. Staphylococcus aureus and Aspergillus fumigatus were the most susceptible among bacteria and fungi tested towards other plant parts. Of interest is the tangible antifungal activity of a Tecoma capensis flower extract, which is reported for the first time. However, minimum inhibitory concentrations (MIC's) for both bacteria and fungi were relatively high (0.5-3.0 mg). As for antiquorum sensing activity against Chromobacterium violaceum, superior activity (>17 mm QS inhibition) was associated with Sonchus oleraceus and Laurus nobilis extracts and weak to good activity (8-17 mm) was recorded for other plants. In conclusion, results indicate the potential of these plant extracts in treating microbial infections through cell growth inhibition or quorum sensing antagonism, which is reported for the first time, thus validating their medicinal use.
Keywords: antimicrobial agents; antiquorum sensing; herbal extracts antimicrobial agents; antiquorum sensing; herbal extracts
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Al-Hussaini, R.; Mahasneh, A.M. Microbial Growth and Quorum Sensing Antagonist Activities of Herbal Plants Extracts. Molecules 2009, 14, 3425-3435.

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