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Molecules 2009, 14(8), 2850-2856; doi:10.3390/molecules14082850
Article

(+)-N-(2-Hydroxypropyl)lindcarpine: A New Cytotoxic Aporphine Isolated from Actinodaphne pruinosa Nees

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1 Department of Chemistry, Faculty of Science and Mathematic, University of Indonesia, Depok, Indonesia 2 Department of Pharmacy, Faculty of Science and Mathematic, National Institute of Science and Technology, Jakarta, Indonesia 3 Centre for Natural Products and Drug Discovery, Block D, Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia 4 Chemistry Department, Faculty of Science and Technology, University of Pendidikan Sultan Idris, Tg. Malim, Perak, Malaysia 5 Research Center for Chemistry, Indonesian Institute of Sciences, Bandung, Indonesia 6 Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa, Tokyo 142-8501, Japan 7 Institut de Chimie des Substances Naturelles, Centre Nationale de la Recherche Scientifique, UPR2301, 91198, Gif-sur-Yvette, Cedex, France
* Author to whom correspondence should be addressed.
Received: 30 June 2009 / Revised: 22 July 2009 / Accepted: 27 July 2009 / Published: 31 July 2009
(This article belongs to the Special Issue Aporphines and Oxoaporphines)
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Abstract

Onenewalkaloid; (+)-N-(2-hydroxypropyl)lindcarpine (1),together with four known aporphine alkaloids, (+)-boldine (2) (+)-norboldine (3), (+)-lindcarpine (4) and (+)-methyllindcarpine (5) were isolated from the stem bark of Actinodaphne pruinosa Nees (Lauraceae). (+)-N-(2-Hydroxypropyl)lindcarpine (1) exhibited cytotoxic activity against P-388 murine leukemia cells with an IC50 value of 3.9 μg/mL. Structural elucidation of all the compounds were performed by spectral methods such as 1D- and 2D- NMR, IR, UV, and HRESIMS.
Keywords: Actinodaphne pruinosa; Lauraceae; aporphine alkaloid; cytotoxic Actinodaphne pruinosa; Lauraceae; aporphine alkaloid; cytotoxic
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Rachmatiah, T.; Mukhtar, M.R.; Nafiah, M.A.; Hanafi, M.; Kosela, S.; Morita, H.; Litaudon, M.; Awang, K.; Omar, H.; Hadi, A.H.A. (+)-N-(2-Hydroxypropyl)lindcarpine: A New Cytotoxic Aporphine Isolated from Actinodaphne pruinosa Nees. Molecules 2009, 14, 2850-2856.

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