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Molecules 2009, 14(8), 2850-2856; doi:10.3390/molecules14082850

(+)-N-(2-Hydroxypropyl)lindcarpine: A New Cytotoxic Aporphine Isolated from Actinodaphne pruinosa Nees

5, 2, 6
3 and 3,*
1 Department of Chemistry, Faculty of Science and Mathematic, University of Indonesia, Depok, Indonesia 2 Department of Pharmacy, Faculty of Science and Mathematic, National Institute of Science and Technology, Jakarta, Indonesia 3 Centre for Natural Products and Drug Discovery, Block D, Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia 4 Chemistry Department, Faculty of Science and Technology, University of Pendidikan Sultan Idris, Tg. Malim, Perak, Malaysia 5 Research Center for Chemistry, Indonesian Institute of Sciences, Bandung, Indonesia 6 Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa, Tokyo 142-8501, Japan 7 Institut de Chimie des Substances Naturelles, Centre Nationale de la Recherche Scientifique, UPR2301, 91198, Gif-sur-Yvette, Cedex, France
* Author to whom correspondence should be addressed.
Received: 30 June 2009 / Revised: 22 July 2009 / Accepted: 27 July 2009 / Published: 31 July 2009
(This article belongs to the Special Issue Aporphines and Oxoaporphines)
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Onenewalkaloid; (+)-N-(2-hydroxypropyl)lindcarpine (1),together with four known aporphine alkaloids, (+)-boldine (2) (+)-norboldine (3), (+)-lindcarpine (4) and (+)-methyllindcarpine (5) were isolated from the stem bark of Actinodaphne pruinosa Nees (Lauraceae). (+)-N-(2-Hydroxypropyl)lindcarpine (1) exhibited cytotoxic activity against P-388 murine leukemia cells with an IC50 value of 3.9 μg/mL. Structural elucidation of all the compounds were performed by spectral methods such as 1D- and 2D- NMR, IR, UV, and HRESIMS.
Keywords: Actinodaphne pruinosa; Lauraceae; aporphine alkaloid; cytotoxic Actinodaphne pruinosa; Lauraceae; aporphine alkaloid; cytotoxic
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Rachmatiah, T.; Mukhtar, M.R.; Nafiah, M.A.; Hanafi, M.; Kosela, S.; Morita, H.; Litaudon, M.; Awang, K.; Omar, H.; Hadi, A.H.A. (+)-N-(2-Hydroxypropyl)lindcarpine: A New Cytotoxic Aporphine Isolated from Actinodaphne pruinosa Nees. Molecules 2009, 14, 2850-2856.

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