Molecules 2009, 14(8), 2850-2856; doi:10.3390/molecules14082850
Article

(+)-N-(2-Hydroxypropyl)lindcarpine: A New Cytotoxic Aporphine Isolated from Actinodaphne pruinosa Nees

Tiah Rachmatiah 1,2 email, Mat Ropi Mukhtar 3 email, Mohd Azlan Nafiah 4 email, Muhammad Hanafi 5 , Soleh Kosela 2 , Hiroshi Morita 6 email, Marc Litaudon 7 email, Khalijah Awang 3 email, Hanita Omar 3  and A. Hamid A. Hadi 3,* email
1 Department of Chemistry, Faculty of Science and Mathematic, University of Indonesia, Depok, Indonesia 2 Department of Pharmacy, Faculty of Science and Mathematic, National Institute of Science and Technology, Jakarta, Indonesia 3 Centre for Natural Products and Drug Discovery, Block D, Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia 4 Chemistry Department, Faculty of Science and Technology, University of Pendidikan Sultan Idris, Tg. Malim, Perak, Malaysia 5 Research Center for Chemistry, Indonesian Institute of Sciences, Bandung, Indonesia 6 Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa, Tokyo 142-8501, Japan 7 Institut de Chimie des Substances Naturelles, Centre Nationale de la Recherche Scientifique, UPR2301, 91198, Gif-sur-Yvette, Cedex, France
* Author to whom correspondence should be addressed.
Received: 30 June 2009; in revised form: 22 July 2009 / Accepted: 27 July 2009 / Published: 31 July 2009
(This article belongs to the Special Issue Aporphines and Oxoaporphines)
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Abstract: Onenewalkaloid; (+)-N-(2-hydroxypropyl)lindcarpine (1),together with four known aporphine alkaloids, (+)-boldine (2) (+)-norboldine (3), (+)-lindcarpine (4) and (+)-methyllindcarpine (5) were isolated from the stem bark of Actinodaphne pruinosa Nees (Lauraceae). (+)-N-(2-Hydroxypropyl)lindcarpine (1) exhibited cytotoxic activity against P-388 murine leukemia cells with an IC50 value of 3.9 μg/mL. Structural elucidation of all the compounds were performed by spectral methods such as 1D- and 2D- NMR, IR, UV, and HRESIMS.
Keywords: Actinodaphne pruinosa; Lauraceae; aporphine alkaloid; cytotoxic

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Cite This Article

MDPI and ACS Style

Rachmatiah, T.; Mukhtar, M.R.; Nafiah, M.A.; Hanafi, M.; Kosela, S.; Morita, H.; Litaudon, M.; Awang, K.; Omar, H.; Hadi, A.H.A. (+)-N-(2-Hydroxypropyl)lindcarpine: A New Cytotoxic Aporphine Isolated from Actinodaphne pruinosa Nees. Molecules 2009, 14, 2850-2856.

AMA Style

Rachmatiah T, Mukhtar MR, Nafiah MA, Hanafi M, Kosela S, Morita H, Litaudon M, Awang K, Omar H, Hadi AHA. (+)-N-(2-Hydroxypropyl)lindcarpine: A New Cytotoxic Aporphine Isolated from Actinodaphne pruinosa Nees. Molecules. 2009; 14(8):2850-2856.

Chicago/Turabian Style

Rachmatiah, Tiah; Mukhtar, Mat Ropi; Nafiah, Mohd Azlan; Hanafi, Muhammad; Kosela, Soleh; Morita, Hiroshi; Litaudon, Marc; Awang, Khalijah; Omar, Hanita; Hadi, A. Hamid A. 2009. "(+)-N-(2-Hydroxypropyl)lindcarpine: A New Cytotoxic Aporphine Isolated from Actinodaphne pruinosa Nees." Molecules 14, no. 8: 2850-2856.

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