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(+)-N-(2-Hydroxypropyl)lindcarpine: A New Cytotoxic Aporphine Isolated from Actinodaphne pruinosa Nees
Department of Chemistry, Faculty of Science and Mathematic, University of Indonesia, Depok, Indonesia
Department of Pharmacy, Faculty of Science and Mathematic, National Institute of Science and Technology, Jakarta, Indonesia
Centre for Natural Products and Drug Discovery, Block D, Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
Chemistry Department, Faculty of Science and Technology, University of Pendidikan Sultan Idris, Tg. Malim, Perak, Malaysia
Research Center for Chemistry, Indonesian Institute of Sciences, Bandung, Indonesia
Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa, Tokyo 142-8501, Japan
Institut de Chimie des Substances Naturelles, Centre Nationale de la Recherche Scientifique, UPR2301, 91198, Gif-sur-Yvette, Cedex, France
* Author to whom correspondence should be addressed.
Received: 30 June 2009; in revised form: 22 July 2009 / Accepted: 27 July 2009 / Published: 31 July 2009
Abstract: Onenewalkaloid; (+)-N-(2-hydroxypropyl)lindcarpine (1),together with four known aporphine alkaloids, (+)-boldine (2) (+)-norboldine (3), (+)-lindcarpine (4) and (+)-methyllindcarpine (5) were isolated from the stem bark of Actinodaphne pruinosa Nees (Lauraceae). (+)-N-(2-Hydroxypropyl)lindcarpine (1) exhibited cytotoxic activity against P-388 murine leukemia cells with an IC50 value of 3.9 μg/mL. Structural elucidation of all the compounds were performed by spectral methods such as 1D- and 2D- NMR, IR, UV, and HRESIMS.
Keywords: Actinodaphne pruinosa; Lauraceae; aporphine alkaloid; cytotoxic
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Rachmatiah, T.; Mukhtar, M.R.; Nafiah, M.A.; Hanafi, M.; Kosela, S.; Morita, H.; Litaudon, M.; Awang, K.; Omar, H.; Hadi, A.H.A. (+)-N-(2-Hydroxypropyl)lindcarpine: A New Cytotoxic Aporphine Isolated from Actinodaphne pruinosa Nees. Molecules 2009, 14, 2850-2856.
Rachmatiah T, Mukhtar MR, Nafiah MA, Hanafi M, Kosela S, Morita H, Litaudon M, Awang K, Omar H, Hadi AHA. (+)-N-(2-Hydroxypropyl)lindcarpine: A New Cytotoxic Aporphine Isolated from Actinodaphne pruinosa Nees. Molecules. 2009; 14(8):2850-2856.
Rachmatiah, Tiah; Mukhtar, Mat Ropi; Nafiah, Mohd Azlan; Hanafi, Muhammad; Kosela, Soleh; Morita, Hiroshi; Litaudon, Marc; Awang, Khalijah; Omar, Hanita; Hadi, A. Hamid A. 2009. "(+)-N-(2-Hydroxypropyl)lindcarpine: A New Cytotoxic Aporphine Isolated from Actinodaphne pruinosa Nees." Molecules 14, no. 8: 2850-2856.