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Molecules 2009, 14(8), 2850-2856; doi:10.3390/molecules14082850
Article

(+)-N-(2-Hydroxypropyl)lindcarpine: A New Cytotoxic Aporphine Isolated from Actinodaphne pruinosa Nees

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Received: 30 June 2009; in revised form: 22 July 2009 / Accepted: 27 July 2009 / Published: 31 July 2009
(This article belongs to the Special Issue Aporphines and Oxoaporphines)
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Abstract: Onenewalkaloid; (+)-N-(2-hydroxypropyl)lindcarpine (1),together with four known aporphine alkaloids, (+)-boldine (2) (+)-norboldine (3), (+)-lindcarpine (4) and (+)-methyllindcarpine (5) were isolated from the stem bark of Actinodaphne pruinosa Nees (Lauraceae). (+)-N-(2-Hydroxypropyl)lindcarpine (1) exhibited cytotoxic activity against P-388 murine leukemia cells with an IC50 value of 3.9 μg/mL. Structural elucidation of all the compounds were performed by spectral methods such as 1D- and 2D- NMR, IR, UV, and HRESIMS.
Keywords: Actinodaphne pruinosa; Lauraceae; aporphine alkaloid; cytotoxic Actinodaphne pruinosa; Lauraceae; aporphine alkaloid; cytotoxic
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Rachmatiah, T.; Mukhtar, M.R.; Nafiah, M.A.; Hanafi, M.; Kosela, S.; Morita, H.; Litaudon, M.; Awang, K.; Omar, H.; Hadi, A.H.A. (+)-N-(2-Hydroxypropyl)lindcarpine: A New Cytotoxic Aporphine Isolated from Actinodaphne pruinosa Nees. Molecules 2009, 14, 2850-2856.

AMA Style

Rachmatiah T, Mukhtar MR, Nafiah MA, Hanafi M, Kosela S, Morita H, Litaudon M, Awang K, Omar H, Hadi AHA. (+)-N-(2-Hydroxypropyl)lindcarpine: A New Cytotoxic Aporphine Isolated from Actinodaphne pruinosa Nees. Molecules. 2009; 14(8):2850-2856.

Chicago/Turabian Style

Rachmatiah, Tiah; Mukhtar, Mat Ropi; Nafiah, Mohd Azlan; Hanafi, Muhammad; Kosela, Soleh; Morita, Hiroshi; Litaudon, Marc; Awang, Khalijah; Omar, Hanita; Hadi, A. Hamid A. 2009. "(+)-N-(2-Hydroxypropyl)lindcarpine: A New Cytotoxic Aporphine Isolated from Actinodaphne pruinosa Nees." Molecules 14, no. 8: 2850-2856.


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