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Molecules 2009, 14(8), 2850-2856; doi:10.3390/molecules14082850
Article

(+)-N-(2-Hydroxypropyl)lindcarpine: A New Cytotoxic Aporphine Isolated from Actinodaphne pruinosa Nees

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Received: 30 June 2009 / Revised: 22 July 2009 / Accepted: 27 July 2009 / Published: 31 July 2009
(This article belongs to the Special Issue Aporphines and Oxoaporphines)
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Abstract

Onenewalkaloid; (+)-N-(2-hydroxypropyl)lindcarpine (1),together with four known aporphine alkaloids, (+)-boldine (2) (+)-norboldine (3), (+)-lindcarpine (4) and (+)-methyllindcarpine (5) were isolated from the stem bark of Actinodaphne pruinosa Nees (Lauraceae). (+)-N-(2-Hydroxypropyl)lindcarpine (1) exhibited cytotoxic activity against P-388 murine leukemia cells with an IC50 value of 3.9 μg/mL. Structural elucidation of all the compounds were performed by spectral methods such as 1D- and 2D- NMR, IR, UV, and HRESIMS.
Keywords: Actinodaphne pruinosa; Lauraceae; aporphine alkaloid; cytotoxic Actinodaphne pruinosa; Lauraceae; aporphine alkaloid; cytotoxic
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Rachmatiah, T.; Mukhtar, M.R.; Nafiah, M.A.; Hanafi, M.; Kosela, S.; Morita, H.; Litaudon, M.; Awang, K.; Omar, H.; Hadi, A.H.A. (+)-N-(2-Hydroxypropyl)lindcarpine: A New Cytotoxic Aporphine Isolated from Actinodaphne pruinosa Nees. Molecules 2009, 14, 2850-2856.

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