Next Article in Journal
(+)-N-(2-Hydroxypropyl)lindcarpine: A New Cytotoxic Aporphine Isolated from Actinodaphne pruinosa Nees
Next Article in Special Issue
Cross-Cyclotrimerization with Two Nitriles as a Synthetic Pathway to Unsymmetrically 3,3’-Disubstituted bis(Tetrahydroisoquinolines)
Previous Article in Journal
Enantiopure Derivatives of Aza-Baylis-Hillman Adducts by Subsequent SN′-SN′ Reactions of Acylcarbamates Bearing a Chiral Auxiliary
Previous Article in Special Issue
Extraction with SPME and Synthesis of 2-Methyl-6-vinylpyrazine by a ‘One Pot’ Reaction Using Microwaves
Molecules 2009, 14(8), 2836-2849; doi:10.3390/molecules14082836
Article

Efficient Microwave Assisted Syntheses of 2,5-Diketopiperazines in Aqueous Media

1, 1, 2 and 1,*
Received: 23 June 2009; in revised form: 21 July 2009 / Accepted: 23 July 2009 / Published: 31 July 2009
(This article belongs to the Special Issue Microwave Assisted Synthesis)
Download PDF [211 KB, uploaded 18 June 2014]
Abstract: Aqueous in situ one-pot N-Boc-deprotection-cyclization of -Boc-dipeptidyl-tert-butyl and methyl esters under microwave irradiation afforded 2,5-diketopiperazines (DKPs) in excellent yields. This protocol is rapid, safe, environmentally friendly, and highly efficient, and showed that the tert-butoxy moiety is also an excellent leaving group for these cyclizations.
Keywords: 2; 5-diketopiperazines; DKPs; cyclic dipeptides; microwave irradiation 2; 5-diketopiperazines; DKPs; cyclic dipeptides; microwave irradiation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Pérez-Picaso, L.; Escalante, J.; Olivo, H.F.; Rios, M.Y. Efficient Microwave Assisted Syntheses of 2,5-Diketopiperazines in Aqueous Media. Molecules 2009, 14, 2836-2849.

AMA Style

Pérez-Picaso L, Escalante J, Olivo HF, Rios MY. Efficient Microwave Assisted Syntheses of 2,5-Diketopiperazines in Aqueous Media. Molecules. 2009; 14(8):2836-2849.

Chicago/Turabian Style

Pérez-Picaso, Lemuel; Escalante, Jaime; Olivo, Horacio F.; Rios, María Yolanda. 2009. "Efficient Microwave Assisted Syntheses of 2,5-Diketopiperazines in Aqueous Media." Molecules 14, no. 8: 2836-2849.


Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert