Molecules 2009, 14(8), 2836-2849; doi:10.3390/molecules14082836
Article

Efficient Microwave Assisted Syntheses of 2,5-Diketopiperazines in Aqueous Media

Received: 23 June 2009; in revised form: 21 July 2009 / Accepted: 23 July 2009 / Published: 31 July 2009
(This article belongs to the Special Issue Microwave Assisted Synthesis)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Aqueous in situ one-pot N-Boc-deprotection-cyclization of -Boc-dipeptidyl-tert-butyl and methyl esters under microwave irradiation afforded 2,5-diketopiperazines (DKPs) in excellent yields. This protocol is rapid, safe, environmentally friendly, and highly efficient, and showed that the tert-butoxy moiety is also an excellent leaving group for these cyclizations.
Keywords: 2; 5-diketopiperazines; DKPs; cyclic dipeptides; microwave irradiation
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MDPI and ACS Style

Pérez-Picaso, L.; Escalante, J.; Olivo, H.F.; Rios, M.Y. Efficient Microwave Assisted Syntheses of 2,5-Diketopiperazines in Aqueous Media. Molecules 2009, 14, 2836-2849.

AMA Style

Pérez-Picaso L, Escalante J, Olivo HF, Rios MY. Efficient Microwave Assisted Syntheses of 2,5-Diketopiperazines in Aqueous Media. Molecules. 2009; 14(8):2836-2849.

Chicago/Turabian Style

Pérez-Picaso, Lemuel; Escalante, Jaime; Olivo, Horacio F.; Rios, María Yolanda. 2009. "Efficient Microwave Assisted Syntheses of 2,5-Diketopiperazines in Aqueous Media." Molecules 14, no. 8: 2836-2849.

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