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Molecules 2009, 14(8), 2836-2849; doi:10.3390/molecules14082836

Efficient Microwave Assisted Syntheses of 2,5-Diketopiperazines in Aqueous Media

Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa, 62209 Cuernavaca, Morelos, México
Medicinal and Natural Products Chemistry, The University of Iowa, Iowa City, IA 52242, USA
Author to whom correspondence should be addressed.
Received: 23 June 2009 / Revised: 21 July 2009 / Accepted: 23 July 2009 / Published: 31 July 2009
(This article belongs to the Special Issue Microwave Assisted Synthesis)
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Aqueous in situ one-pot N-Boc-deprotection-cyclization of -Boc-dipeptidyl-tert-butyl and methyl esters under microwave irradiation afforded 2,5-diketopiperazines (DKPs) in excellent yields. This protocol is rapid, safe, environmentally friendly, and highly efficient, and showed that the tert-butoxy moiety is also an excellent leaving group for these cyclizations.
Keywords: 2; 5-diketopiperazines; DKPs; cyclic dipeptides; microwave irradiation 2; 5-diketopiperazines; DKPs; cyclic dipeptides; microwave irradiation

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Pérez-Picaso, L.; Escalante, J.; Olivo, H.F.; Rios, M.Y. Efficient Microwave Assisted Syntheses of 2,5-Diketopiperazines in Aqueous Media. Molecules 2009, 14, 2836-2849.

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