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Molecules 2009, 14(7), 2491-2500; doi:10.3390/molecules14072491
Article

Leishmanicidal Activity of Aliphatic and Aromatic Lactones: Correlation Structure-Activity

1, 2, 1, 3 and 1,*
1 Grupo de Química Orgánica de Productos Naturales-SIU, Universidad de Antioquia, P.O. Box 1226, Medellín, Colombia 2 Instituto de Química, Universidad de Antioquia, Universidad de Antioquia, P.O. Box 1226, Medellín, Colombia 3 PECET-SIU, Universidad de Antioquia, P.O. Box 1226, Medellín, Colombia
* Author to whom correspondence should be addressed.
Received: 7 June 2009 / Accepted: 18 June 2009 / Published: 10 July 2009
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Abstract

Several aliphatic and aromatic lactones and two dimers were synthesized using the sequence: allylation - esterification - metathesis. These compounds were active in vitro against intracellular amastigotes of Leishmania panamensis. The structure-activity relationship showed the importance of the aliphatic side chain to enhance the biological activity and to obtain lower cytotoxicity. It was also observed that a decrease in the size of the lactone ring increases the selectivity index.
Keywords: metathesis; lactones; antiparasite; leishmania metathesis; lactones; antiparasite; leishmania
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Castaño, M.; Cardona, W.; Quiñones, W.; Robledo, S.; Echeverri, F. Leishmanicidal Activity of Aliphatic and Aromatic Lactones: Correlation Structure-Activity. Molecules 2009, 14, 2491-2500.

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