Molecules 2009, 14(7), 2491-2500; doi:10.3390/molecules14072491
Article

Leishmanicidal Activity of Aliphatic and Aromatic Lactones: Correlation Structure-Activity

Received: 7 June 2009; Accepted: 18 June 2009 / Published: 10 July 2009
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Several aliphatic and aromatic lactones and two dimers were synthesized using the sequence: allylation - esterification - metathesis. These compounds were active in vitro against intracellular amastigotes of Leishmania panamensis. The structure-activity relationship showed the importance of the aliphatic side chain to enhance the biological activity and to obtain lower cytotoxicity. It was also observed that a decrease in the size of the lactone ring increases the selectivity index.
Keywords: metathesis; lactones; antiparasite; leishmania
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MDPI and ACS Style

Castaño, M.; Cardona, W.; Quiñones, W.; Robledo, S.; Echeverri, F. Leishmanicidal Activity of Aliphatic and Aromatic Lactones: Correlation Structure-Activity. Molecules 2009, 14, 2491-2500.

AMA Style

Castaño M, Cardona W, Quiñones W, Robledo S, Echeverri F. Leishmanicidal Activity of Aliphatic and Aromatic Lactones: Correlation Structure-Activity. Molecules. 2009; 14(7):2491-2500.

Chicago/Turabian Style

Castaño, Marcela; Cardona, Wilson; Quiñones, Winston; Robledo, Sara; Echeverri, Fernando. 2009. "Leishmanicidal Activity of Aliphatic and Aromatic Lactones: Correlation Structure-Activity." Molecules 14, no. 7: 2491-2500.

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