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Molecules 2009, 14(7), 2491-2500; doi:10.3390/molecules14072491

Leishmanicidal Activity of Aliphatic and Aromatic Lactones: Correlation Structure-Activity

1, 2, 1, 3 and 1,*
Received: 7 June 2009 / Accepted: 18 June 2009 / Published: 10 July 2009
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Several aliphatic and aromatic lactones and two dimers were synthesized using the sequence: allylation - esterification - metathesis. These compounds were active in vitro against intracellular amastigotes of Leishmania panamensis. The structure-activity relationship showed the importance of the aliphatic side chain to enhance the biological activity and to obtain lower cytotoxicity. It was also observed that a decrease in the size of the lactone ring increases the selectivity index.
Keywords: metathesis; lactones; antiparasite; leishmania metathesis; lactones; antiparasite; leishmania
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Castaño, M.; Cardona, W.; Quiñones, W.; Robledo, S.; Echeverri, F. Leishmanicidal Activity of Aliphatic and Aromatic Lactones: Correlation Structure-Activity. Molecules 2009, 14, 2491-2500.

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