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Molecules 2009, 14(5), 1773-1780; doi:10.3390/molecules14051773

Antibacterial Activity of Methyl Gallate Isolated from Galla Rhois or Carvacrol Combined with Nalidixic Acid Against Nalidixic Acid Resistant Bacteria

1
Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Wonkwang Oriental Medicines Research Institute, Jeonbuk 570-749, Korea
2
Department of Oriental Medicine Resources, Sunchon National University, Jeonnam 540-742, Korea
*
Author to whom correspondence should be addressed.
Received: 17 March 2009 / Revised: 4 May 2009 / Accepted: 6 May 2009 / Published: 11 May 2009
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Abstract

Methyl gallate is a major component of Galla Rhois, as carvacrol is of oregano essential oils. Both have shown good antibacterial activity against intestinal bacteria. This study investigated the antibacterial activities of nalidixic acid in combination with methyl gallate and carvacrol against nalidixic acid resistant bacteria. The combined effect of nalidixic acid with methyl gallate and carvacrol was evaluated using the checkerboard method to obtain a fractional inhibitory concentration index. The results showed that the combinations of nalidixic acid + methyl gallate/carvacrol improved nalidixic acid resistant pathogenic bacteria inhibition with synergy or partial synergy activity. Thus, a strong bactericidal effect of the drug combinations was observed. In vitro data thus suggested that nalidixic acid combined with methyl gallate and carvacrol may be microbiologically beneficial, rather than antagonists.
Keywords: Nalidixic acid-resistant bacteria; methyl gallate; carvacrol; antibacterial activity; combination Nalidixic acid-resistant bacteria; methyl gallate; carvacrol; antibacterial activity; combination
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Choi, J.-G.; Kang, O.-H.; Lee, Y.-S.; Oh, Y.-C.; Chae, H.-S.; Jang, H.-J.; Shin, D.-W.; Kwon, D.-Y. Antibacterial Activity of Methyl Gallate Isolated from Galla Rhois or Carvacrol Combined with Nalidixic Acid Against Nalidixic Acid Resistant Bacteria. Molecules 2009, 14, 1773-1780.

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