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Molecules 2009, 14(5), 1747-1754; doi:10.3390/molecules14051747

Synthesis, Characterization, Crystal Structure and Antibacterial Activities of Transition Metal(II) Complexes of the Schiff Base 2-[(4-Methylphenylimino)methyl]-6-methoxyphenol

1
Jinhua College of Profession & Technology, Jinhua 321017, P. R. China
2
Zhejiang Key Laboratory for Reactive Chemistry on Solid Surfaces, Institute of Physical Chemistry, College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua, 321004, P. R. China
*
Author to whom correspondence should be addressed.
Received: 3 April 2009 / Revised: 19 April 2009 / Accepted: 30 April 2009 / Published: 7 May 2009
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Abstract

Five transition metal(II) complexes, [ML2Cl2] 1~5, were synthesized from the reaction of MCl2·nH2O (M = Mn, Co, Ni, Cu, Cd) and the Schiff base ligand 2-[(4-methylphenylimino)methyl]-6-methoxyphenol (C15H15NO2, L), obtained by condensation of o-vanillin (2-hydroxy-3-methoxybenzaldehyde) with p-toluidine. They were characterized by elemental analysis, molar conductance, FT-IR spectra, thermal analysis. The structure of complex 1 was determined by single-crystal X-ray diffraction. Its crystal structure is of monoclinic system, space group P21/c with a = 9.0111(18) Å, b = 11.222(2) Å, c =28.130 (6) Å, α = 90 º, β = 92.29(3) º, γ = 90 º, V = 2867.6(10) Å3, Z = 4. The Mn atom is six-coordinate and displays distorted octahedral geometry.The Schiff base ligand and its complexes have been tested in vitro to evaluate their antibacterial activity against bacteria, viz., Escherichia coli, Staphylococcus aureus and Bacillus subtilis. It has been found that the complexes have higher activity than the corresponding free Schiff base ligand against the same bacteria.
Keywords: Transition metal(II) complex; crystal structure; Schiff base; antibacterial activity Transition metal(II) complex; crystal structure; Schiff base; antibacterial activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Yu, Y.-Y.; Xian, H.-D.; Liu, J.-F.; Zhao, G.-L. Synthesis, Characterization, Crystal Structure and Antibacterial Activities of Transition Metal(II) Complexes of the Schiff Base 2-[(4-Methylphenylimino)methyl]-6-methoxyphenol. Molecules 2009, 14, 1747-1754.

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