Recent Developments in the Chemistry of Deoxyribonucleic Acid (DNA) Intercalators: Principles, Design, Synthesis, Applications and Trends

doi:10.3390/molecules14051725

This article is

freely available
re-usable

Molecules 2009, 14(5), 1725-1746; doi:10.3390/molecules14051725

Review

Recent Developments in the Chemistry of Deoxyribonucleic Acid (DNA) Intercalators: Principles, Design, Synthesis, Applications and Trends

Brenno A.D. Neto ¹^,* and Alexandre A.M. Lapis ²

¹ Laboratory of Medicinal and Technological Chemistry, University of Brasilia (IQ-UnB), Brasilia, DF, Brazil ² Universidade Federal do Pampa, Unipampa, Bagé, RS, Brazil

* Author to whom correspondence should be addressed.

Received: 15 February 2009; in revised form: 20 April 2009 / Accepted: 5 May 2009 / Published: 7 May 2009

(This article belongs to the Special Issue Nucleic Acids)

Download PDF Full-Text [236 KB, uploaded 7 May 2009 05:46 CET]

Abstract: In the present overview, we describe the bases of intercalation of small molecules (cationic and polar neutral compounds) in DNA. We briefly describe the importance of DNA structure and principles of intercalation. Selected syntheses, possibilities and applications are shown to exemplify the importance, drawbacks and challenges in this pertinent, new, and exciting research area. Additionally, some clinical applications (molecular processes, cancer therapy and others) and trends are described.

Keywords: DNA; RNA; photointercalators; fluorescence; rational design; therapy; cancer

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Neto, B.A.D.; Lapis, A.A.M. Recent Developments in the Chemistry of Deoxyribonucleic Acid (DNA) Intercalators: Principles, Design, Synthesis, Applications and Trends. Molecules 2009, 14, 1725-1746.

AMA Style

Neto B.A.D., Lapis A.A.M. Recent Developments in the Chemistry of Deoxyribonucleic Acid (DNA) Intercalators: Principles, Design, Synthesis, Applications and Trends. Molecules. 2009; 14(5):1725-1746.

Chicago/Turabian Style

Neto, Brenno A.D.; Lapis, Alexandre A.M. 2009. "Recent Developments in the Chemistry of Deoxyribonucleic Acid (DNA) Intercalators: Principles, Design, Synthesis, Applications and Trends." Molecules 14, no. 5: 1725-1746.

Molecules EISSN 1420-3049 Published by MDPI Publishing, Basel, Switzerland RSS E-Mail Table of Contents Alert