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Molecules 2009, 14(5), 1725-1746; doi:10.3390/molecules14051725
Review

Recent Developments in the Chemistry of Deoxyribonucleic Acid (DNA) Intercalators: Principles, Design, Synthesis, Applications and Trends

1,*  and 2
Received: 15 February 2009 / Revised: 20 April 2009 / Accepted: 5 May 2009 / Published: 7 May 2009
(This article belongs to the Special Issue Nucleic Acids)
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Abstract

In the present overview, we describe the bases of intercalation of small molecules (cationic and polar neutral compounds) in DNA. We briefly describe the importance of DNA structure and principles of intercalation. Selected syntheses, possibilities and applications are shown to exemplify the importance, drawbacks and challenges in this pertinent, new, and exciting research area. Additionally, some clinical applications (molecular processes, cancer therapy and others) and trends are described.
Keywords: DNA; RNA; photointercalators; fluorescence; rational design; therapy; cancer DNA; RNA; photointercalators; fluorescence; rational design; therapy; cancer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Neto, B.A.D.; Lapis, A.A.M. Recent Developments in the Chemistry of Deoxyribonucleic Acid (DNA) Intercalators: Principles, Design, Synthesis, Applications and Trends. Molecules 2009, 14, 1725-1746.

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