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Molecules 2009, 14(4), 1537-1545; doi:10.3390/molecules14041537
Article

Determination of Proton Relaxivities of Mn(II), Cu(II) and Cr(III) added to Solutions of Serum Proteins

* ,  and
Department of Physics, University of Dicle, 21280 Diyarbakir, Turkey
* Author to whom correspondence should be addressed.
Received: 26 February 2009 / Revised: 18 March 2009 / Accepted: 10 April 2009 / Published: 14 April 2009
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Abstract

Relaxometric studies are still of scientific interest due to their use in medicine and biology. In this study, proton T1 and T2 relaxivities of Mn(II), Cu(II) and Cr(III) in water were determined in the presence and absence of various proteins (albumin, α-globulin, γ-globulin, lysozyme, fibrinogen). The 1/T1 and 1/T2 in all solutions are linearly proportional to the concentration of the paramagnetic ions. Mn(II) has the great influence to alter relaxations in all protein solutions, while Cu(II) and Cr(III) have a poor influence on the relaxations. In addition, Mn(II) and Cu(II) are bound to each protein, but Cr(III) is not bound to any protein.
Keywords: MRI; T1; T2; Mn(II); Cu(II); Cr(III); Serum proteins MRI; T1; T2; Mn(II); Cu(II); Cr(III); Serum proteins
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Köylü, M.Z.; Asubay, S.; Yilmaz, A. Determination of Proton Relaxivities of Mn(II), Cu(II) and Cr(III) added to Solutions of Serum Proteins. Molecules 2009, 14, 1537-1545.

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