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Molecules 2009, 14(4), 1423-1428; doi:10.3390/molecules14041423
Communication

Ultrasound Promoted Synthesis of Bis(substituted pyrazol-4-ylcarbonyl)-Substituted Thioureas

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School of Chemistry and Chemical Engineering, Xinjiang University, Key Laboratory of Oil and Gas Fine Chemicals, Ministry of Education, 830046 Urumqi, P. R. China
* Author to whom correspondence should be addressed.
Received: 28 February 2009 / Revised: 15 March 2009 / Accepted: 23 March 2009 / Published: 31 March 2009
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Abstract

A series of novel bis(substituted pyrazol-4-ylcarbonyl)-substituted thioureas have been synthesized by the reactions of substituted pyrazol-4-ylcarbonyl isothiocyanates with different diamines under ultrasound irradiation and classical heating method at 20-25 °C. In general, substantial improvement in rates and modest yields increases were observed when reactions were carried out under sonication, compared with the classical heating method. The structures of these compounds have been elucidated by elemental and spectral (IR, 1H-NMR) analysis.
Keywords: Thiourea; Pyrazole; Diamine; Ultrasound; Synthesis Thiourea; Pyrazole; Diamine; Ultrasound; Synthesis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Xiao, L.; Liu, C.-J.; Li, Y.-P. Ultrasound Promoted Synthesis of Bis(substituted pyrazol-4-ylcarbonyl)-Substituted Thioureas. Molecules 2009, 14, 1423-1428.

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