• Abstract
• Full-Text PDF [102 KB]

• Article Statistics
• PubMed/Medline
• Google Scholar
• Order Reprints

• Cite this article
• Export to BibTeX
• Export to EndNote

• [+] on DOAJ
• Laphookhieo, S
• Maneerat, W
• Koysomboon, S
• [+] on Google Scholar
• Laphookhieo, S
• Maneerat, W
• Koysomboon, S
• [+] on PubMed
• Laphookhieo, S
• Maneerat, W
• Koysomboon, S

•  CiteULike
•  Facebook
•  Mendeley
•  Twitter

This article is

• freely available
• re-usable

Molecules 2009, 14(4), 1389-1395; doi:10.3390/molecules14041389

Article

Antimalarial and Cytotoxic Phenolic Compounds from Cratoxylum maingayi and Cratoxylum cochinchinense

Surat Laphookhieo ^1,* , Wisanu Maneerat ^1,*  and Sorwaporn Koysomboon ²

¹ School of Science, Mae Fah Luang University; Tasud, Muang, Chiang Rai 57100, Thailand ² Faculty of Science and Industrial Technology, Prince of Songkla University, Muang, Suratthani, Thailand

* Authors to whom correspondence should be addressed.

Received: 13 February 2009; in revised form: 23 March 2009 / Accepted: 23 March 2009 / Published: 30 March 2009

Download PDF Full-Text [102 KB, uploaded 14 April 2009 09:05 CEST]

Abstract: Nine phenolic compounds isolated from Cratoxylum maingayi and C. cochinchinense were evaluated for anti-malarial activity against Plasmodium falciparum, and for cytotoxic activity against the NCI-H187 (human small cell lung cancer) cancer cell line. Formoxanthone C (3) was found to be the most active against the NCI-H187 cancer cell line, with an IC₅₀ of 0.22 mg/mL, while vismione B (7) had the highest activity against Plasmodium falciparum, with an IC₅₀ of 0.66 mg/mL.

Keywords: Cratoxylum maingayi; C. cochinchinense; Xanthones; Anti-malarial activity; Cytotoxic activity

Article Statistics

Cite This Article