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Molecules 2009, 14(4), 1389-1395; doi:10.3390/molecules14041389
Article

Antimalarial and Cytotoxic Phenolic Compounds from Cratoxylum maingayi and Cratoxylum cochinchinense

1,* , 1,*  and 2
1 School of Science, Mae Fah Luang University; Tasud, Muang, Chiang Rai 57100, Thailand 2 Faculty of Science and Industrial Technology, Prince of Songkla University, Muang, Suratthani, Thailand
* Authors to whom correspondence should be addressed.
Received: 13 February 2009 / Revised: 23 March 2009 / Accepted: 23 March 2009 / Published: 30 March 2009
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Abstract

Nine phenolic compounds isolated from Cratoxylum maingayi and C. cochinchinense were evaluated for anti-malarial activity against Plasmodium falciparum, and for cytotoxic activity against the NCI-H187 (human small cell lung cancer) cancer cell line. Formoxanthone C (3) was found to be the most active against the NCI-H187 cancer cell line, with an IC50 of 0.22 mg/mL, while vismione B (7) had the highest activity against Plasmodium falciparum, with an IC50 of 0.66 mg/mL.
Keywords: Cratoxylum maingayi; C. cochinchinense; Xanthones; Anti-malarial activity; Cytotoxic activity Cratoxylum maingayi; C. cochinchinense; Xanthones; Anti-malarial activity; Cytotoxic activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Laphookhieo, S.; Maneerat, W.; Koysomboon, S. Antimalarial and Cytotoxic Phenolic Compounds from Cratoxylum maingayi and Cratoxylum cochinchinense. Molecules 2009, 14, 1389-1395.

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