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Molecules 2009, 14(4), 1389-1395; doi:10.3390/molecules14041389
Article

Antimalarial and Cytotoxic Phenolic Compounds from Cratoxylum maingayi and Cratoxylum cochinchinense

1,* , 1,*  and 2
1 School of Science, Mae Fah Luang University; Tasud, Muang, Chiang Rai 57100, Thailand 2 Faculty of Science and Industrial Technology, Prince of Songkla University, Muang, Suratthani, Thailand
* Authors to whom correspondence should be addressed.
Received: 13 February 2009 / Revised: 23 March 2009 / Accepted: 23 March 2009 / Published: 30 March 2009
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Abstract

Nine phenolic compounds isolated from Cratoxylum maingayi and C. cochinchinense were evaluated for anti-malarial activity against Plasmodium falciparum, and for cytotoxic activity against the NCI-H187 (human small cell lung cancer) cancer cell line. Formoxanthone C (3) was found to be the most active against the NCI-H187 cancer cell line, with an IC50 of 0.22 mg/mL, while vismione B (7) had the highest activity against Plasmodium falciparum, with an IC50 of 0.66 mg/mL.
Keywords: Cratoxylum maingayi; C. cochinchinense; Xanthones; Anti-malarial activity; Cytotoxic activity Cratoxylum maingayi; C. cochinchinense; Xanthones; Anti-malarial activity; Cytotoxic activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Laphookhieo, S.; Maneerat, W.; Koysomboon, S. Antimalarial and Cytotoxic Phenolic Compounds from Cratoxylum maingayi and Cratoxylum cochinchinense. Molecules 2009, 14, 1389-1395.

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