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Flavonoids with Gastroprotective Activity
Laboratório de Tecnologia Farmacêutica Prof. Delby Fernandes de Medeiros – LTF, Universidade Federal da Paraíba - UFPB, Cx. Postal 5009, 58051-970, João Pessoa, PB, Brazil
Laboratório de Produtos Naturais, Universidade Estadual de Campinas - UNICAMP, Cx. Postal 6109, 13083-970, Campinas, SP, Brazil
Departamento de Fisiologia, Instituto de Biosciência, São Paulo, Universidade Estadual de São Paulo UNESP, c.p. 510, Zip Code: 18618-000, Botucatu, SP, Brazil
* Author to whom correspondence should be addressed.
Received: 30 November 2008; in revised form: 7 January 2009 / Accepted: 6 February 2009 / Published: 3 March 2009
Abstract: Peptic ulcers are a common disorder of the entire gastrointestinal tract that occurs mainly in the stomach and the proximal duodenum. This disease is multifactorial and its treatment faces great difficulties due to the limited effectiveness and severe side effects of the currently available drugs. The use of natural products for the prevention and treatment of different pathologies is continuously expanding throughout the world. This is particularly true with regards to flavonoids, which represent a highly diverse class of secondary metabolites with potentially beneficial human health effects that is widely distributed in the plant kingdom and currently consumed in large amounts in the diet. They display several pharmacological properties in the gastroprotective area, acting as anti-secretory, cytoprotective and antioxidant agents. Besides their action as gastroprotectives, flavonoids also act in healing of gastric ulcers and additionally these polyphenolic compounds can be new alternatives for suppression or modulation of peptic ulcers associated with H. pylori. In this review, we have summarized the literature on ninety-five flavonoids with varying degrees of antiulcerogenic activity, confirming that flavonoids have a therapeutic potential for the more effective treatment of peptic ulcers.
Keywords: Flavonoids; Gastroprotective activity; Peptic ulcers; Natural products
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MDPI and ACS Style
de Lira Mota, K.S.; Dias, G.E.N.; Pinto, M.E.F.; Luiz-Ferreira, Â.; Monteiro Souza-Brito, A.R.; Hiruma-Lima, C.A.; Barbosa-Filho, J.M.; Batista, L.M. Flavonoids with Gastroprotective Activity. Molecules 2009, 14, 979-1012.
de Lira Mota KS, Dias GEN, Pinto MEF, Luiz-Ferreira Â, Monteiro Souza-Brito AR, Hiruma-Lima CA, Barbosa-Filho JM, Batista LM. Flavonoids with Gastroprotective Activity. Molecules. 2009; 14(3):979-1012.
de Lira Mota, Kelly Samara; Dias, Guilherme Eduardo Nunes; Pinto, Meri Emili Ferreira; Luiz-Ferreira, Ânderson; Monteiro Souza-Brito, Alba Regina; Hiruma-Lima, Clélia Akiko; Barbosa-Filho, José Maria; Batista, Leônia Maria. 2009. "Flavonoids with Gastroprotective Activity." Molecules 14, no. 3: 979-1012.