Molecules 2009, 14(2), 586-597; doi:10.3390/molecules14020586
Article

Antimicrobial Activity of Five Herbal Extracts Against Multi Drug Resistant (MDR) Strains of Bacteria and Fungus of Clinical Origin

Rosina Khan 1, 3 email, Barira Islam 1 email, Mohd Akram 1 email, Shazi Shakil 1 email, Anis Ahmad Ahmad 1 , S. Manazir Ali 2 email, Mashiatullah Siddiqui 3 email and Asad U. Khan 1,* email
1 Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, India 2 Department of Pediatrics, J N Medical College and Hospital, AMU, Aligarh, India 3 Department of Biochemistry, J N Medical College and Hospital, AMU, Aligarh, India
* Author to whom correspondence should be addressed.
Received: 15 September 2008; in revised form: 8 October 2008 / Accepted: 3 February 2009 / Published: 4 February 2009
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Abstract: Antimicrobial activities of the crude ethanolic extracts of five plants were screened against multidrug resistant (MDR) strains of Escherichia coli, Klebsiella pneumoniae and Candida albicans. ATCCstrains of Streptococcus mutans, Staphylococcus aureus, Enterococcus faecalis, Streptococcus bovis, Pseudimonas aeruginosa, Salmonella typhimurium, Escherichia coli, Klebsiella pneumoniae and Candida albicans were also tested. The strains that showed resistance against the maximum number of antibiotics tested were selected for an antibacterial assay. The MDR strains were sensitive to the antimicrobial activity of Acacia nilotica, Syzygium aromaticum and Cinnamum zeylanicum, whereas they exhibited strong resistance to the extracts of Terminalia arjuna and Eucalyptus globulus. Community-acquired infections showed higher sensitivity than the nosocomial infections against these extracts. The most potent antimicrobial plant was A. nilotica (MIC range 9.75-313µg/ml), whereas other crude plant extracts studied in this report were found to exhibit higher MIC values than A. nilotica against community acquired as well as nosocomial infection. This study concludes that A. nilotica, C. zeylanicum and S. aromaticum can be used against multidrug resistant microbes causing nosocomial and community acquired infections.
Keywords: Herbal extracts; Antimicrobial agent; Multi-drug resistant

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Cite This Article

MDPI and ACS Style

Khan, R.; Islam, B.; Akram, M.; Shakil, S.; Ahmad, A.A.; Ali, S.M.; Siddiqui, M.; Khan, A.U. Antimicrobial Activity of Five Herbal Extracts Against Multi Drug Resistant (MDR) Strains of Bacteria and Fungus of Clinical Origin. Molecules 2009, 14, 586-597.

AMA Style

Khan R, Islam B, Akram M, Shakil S, Ahmad AA, Ali SM, Siddiqui M, Khan AU. Antimicrobial Activity of Five Herbal Extracts Against Multi Drug Resistant (MDR) Strains of Bacteria and Fungus of Clinical Origin. Molecules. 2009; 14(2):586-597.

Chicago/Turabian Style

Khan, Rosina; Islam, Barira; Akram, Mohd; Shakil, Shazi; Ahmad, Anis Ahmad; Ali, S. Manazir; Siddiqui, Mashiatullah; Khan, Asad U. 2009. "Antimicrobial Activity of Five Herbal Extracts Against Multi Drug Resistant (MDR) Strains of Bacteria and Fungus of Clinical Origin." Molecules 14, no. 2: 586-597.

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