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Molecules’ Highlights in 2008 and a Look Forward to 2009
Molecules 2009, 14(2), 586-597; doi:10.3390/molecules14020586
Article

Antimicrobial Activity of Five Herbal Extracts Against Multi Drug Resistant (MDR) Strains of Bacteria and Fungus of Clinical Origin

1, 3
, 1
, 1
, 1
, 1, 2
, 3
 and 1,*
1 Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, India 2 Department of Pediatrics, J N Medical College and Hospital, AMU, Aligarh, India 3 Department of Biochemistry, J N Medical College and Hospital, AMU, Aligarh, India
* Author to whom correspondence should be addressed.
Received: 15 September 2008 / Revised: 8 October 2008 / Accepted: 3 February 2009 / Published: 4 February 2009
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Abstract

Antimicrobial activities of the crude ethanolic extracts of five plants were screened against multidrug resistant (MDR) strains of Escherichia coli, Klebsiella pneumoniae and Candida albicans. ATCCstrains of Streptococcus mutans, Staphylococcus aureus, Enterococcus faecalis, Streptococcus bovis, Pseudimonas aeruginosa, Salmonella typhimurium, Escherichia coli, Klebsiella pneumoniae and Candida albicans were also tested. The strains that showed resistance against the maximum number of antibiotics tested were selected for an antibacterial assay. The MDR strains were sensitive to the antimicrobial activity of Acacia nilotica, Syzygium aromaticum and Cinnamum zeylanicum, whereas they exhibited strong resistance to the extracts of Terminalia arjuna and Eucalyptus globulus. Community-acquired infections showed higher sensitivity than the nosocomial infections against these extracts. The most potent antimicrobial plant was A. nilotica (MIC range 9.75-313µg/ml), whereas other crude plant extracts studied in this report were found to exhibit higher MIC values than A. nilotica against community acquired as well as nosocomial infection. This study concludes that A. nilotica, C. zeylanicum and S. aromaticum can be used against multidrug resistant microbes causing nosocomial and community acquired infections.
Keywords: Herbal extracts; Antimicrobial agent; Multi-drug resistant Herbal extracts; Antimicrobial agent; Multi-drug resistant
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Khan, R.; Islam, B.; Akram, M.; Shakil, S.; Ahmad, A.A.; Ali, S.M.; Siddiqui, M.; Khan, A.U. Antimicrobial Activity of Five Herbal Extracts Against Multi Drug Resistant (MDR) Strains of Bacteria and Fungus of Clinical Origin. Molecules 2009, 14, 586-597.

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