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Molecules 2009, 14(12), 5382-5388; doi:10.3390/molecules14125382

New Conjugated Benzothiazole-N-oxides: Synthesis and Biological Activity

1
Department of Organic Chemistry, Faculty of Natural Sciences, Comenius University, Mlynská dolina CH-2, 842 15 Bratislava, Slovakia
2
Institute of Subcellular Biology, Faculty of Natural Sciences, Comenius University, Mlynská dolina CH-2, 842 15 Bratislava, Slovakia
*
Author to whom correspondence should be addressed.
Received: 28 October 2009 / Revised: 12 December 2009 / Accepted: 18 December 2009 / Published: 23 December 2009
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Abstract

Eleven new 2-styrylbenzothiazole-N-oxides have been prepared by aldol – type condensation reactions between 2-methylbenzothiazole–N-oxide and para-substituted benzaldehydes. Compounds with cyclic amino substituents showed typical push-pull molecule properties. Four compounds were tested against various bacterial strains as well as the protozoan Euglena gracilis as model microorganisms. Unlike previously prepared analogous benzothiazolium salts, only weak activity was recorded.
Keywords: benzothiazole; N-oxides; push-pull systems; antibacterial; Euglena gracilis benzothiazole; N-oxides; push-pull systems; antibacterial; Euglena gracilis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Gajdoš, P.; Magdolen, P.; Zahradník, P.; Foltínová, P. New Conjugated Benzothiazole-N-oxides: Synthesis and Biological Activity. Molecules 2009, 14, 5382-5388.

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