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Molecules 2009, 14(12), 5042-5053; doi:10.3390/molecules14125042
Article

Synthesis and Antitumor Activities of Phenanthrene-Based Alkaloids

1,†, 1,†, 1, 1, 1, 1, 1,*  and 2,*
Received: 26 October 2009; in revised form: 25 November 2009 / Accepted: 2 December 2009 / Published: 7 December 2009
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Abstract: A series of phenanthrene-based tylophorine derivatives (PBTs) were synthesized and their cytotoxic activities against the H460 human large-cell lung carcinoma cell line were evaluated. Among these compounds, N-(3-hydroxy-2,6,7-tri-methoxyphenanthr-9-ylmethyl)-L-prolinol (5a), and N-(3-hydroxy-2,6,7-trimethoxy-phenanthr-9-ylmethyl)-L-valinol (9) exhibited good activities, with IC50 values of 11.6 and 6.1 mM, respectively.
Keywords: PBTs; synthesis; cytotoxicity PBTs; synthesis; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Li, S.; Han, L.; Sun, L.; Zheng, D.; Liu, J.; Fu, Y.; Huang, X.; Wang, Z. Synthesis and Antitumor Activities of Phenanthrene-Based Alkaloids. Molecules 2009, 14, 5042-5053.

AMA Style

Li S, Han L, Sun L, Zheng D, Liu J, Fu Y, Huang X, Wang Z. Synthesis and Antitumor Activities of Phenanthrene-Based Alkaloids. Molecules. 2009; 14(12):5042-5053.

Chicago/Turabian Style

Li, Songtao; Han, Li; Sun, Liang; Zheng, Dan; Liu, Jiang; Fu, Yingbo; Huang, Xueshi; Wang, Zhanyou. 2009. "Synthesis and Antitumor Activities of Phenanthrene-Based Alkaloids." Molecules 14, no. 12: 5042-5053.



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