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Molecules 2009, 14(12), 5042-5053; doi:10.3390/molecules14125042
Article

Synthesis and Antitumor Activities of Phenanthrene-Based Alkaloids

1,†, 1,†, 1, 1, 1, 1, 1,*  and 2,*
1 Department of Natural Products Chemistry, Pharmaceutical School, China Medical University, Shenyang 110001, China 2 Laboratory of Cell Engineering and Cell Therapy, College of Basic Medical Science, China Medical University, Shenyang 110001, China These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 26 October 2009 / Revised: 25 November 2009 / Accepted: 2 December 2009 / Published: 7 December 2009
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Abstract

A series of phenanthrene-based tylophorine derivatives (PBTs) were synthesized and their cytotoxic activities against the H460 human large-cell lung carcinoma cell line were evaluated. Among these compounds, N-(3-hydroxy-2,6,7-tri-methoxyphenanthr-9-ylmethyl)-L-prolinol (5a), and N-(3-hydroxy-2,6,7-trimethoxy-phenanthr-9-ylmethyl)-L-valinol (9) exhibited good activities, with IC50 values of 11.6 and 6.1 mM, respectively.
Keywords: PBTs; synthesis; cytotoxicity PBTs; synthesis; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Li, S.; Han, L.; Sun, L.; Zheng, D.; Liu, J.; Fu, Y.; Huang, X.; Wang, Z. Synthesis and Antitumor Activities of Phenanthrene-Based Alkaloids. Molecules 2009, 14, 5042-5053.

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