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Synthesis and Antitumor Activities of Phenanthrene-Based Alkaloids
Department of Natural Products Chemistry, Pharmaceutical School, China Medical University, Shenyang 110001, China
Laboratory of Cell Engineering and Cell Therapy, College of Basic Medical Science, China Medical University, Shenyang 110001, China
These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 26 October 2009; in revised form: 25 November 2009 / Accepted: 2 December 2009 / Published: 7 December 2009
Abstract: A series of phenanthrene-based tylophorine derivatives (PBTs) were synthesized and their cytotoxic activities against the H460 human large-cell lung carcinoma cell line were evaluated. Among these compounds, N-(3-hydroxy-2,6,7-tri-methoxyphenanthr-9-ylmethyl)-L-prolinol (5a), and N-(3-hydroxy-2,6,7-trimethoxy-phenanthr-9-ylmethyl)-L-valinol (9) exhibited good activities, with IC50 values of 11.6 and 6.1 mM, respectively.
Keywords: PBTs; synthesis; cytotoxicity
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Li, S.; Han, L.; Sun, L.; Zheng, D.; Liu, J.; Fu, Y.; Huang, X.; Wang, Z. Synthesis and Antitumor Activities of Phenanthrene-Based Alkaloids. Molecules 2009, 14, 5042-5053.
Li S, Han L, Sun L, Zheng D, Liu J, Fu Y, Huang X, Wang Z. Synthesis and Antitumor Activities of Phenanthrene-Based Alkaloids. Molecules. 2009; 14(12):5042-5053.
Li, Songtao; Han, Li; Sun, Liang; Zheng, Dan; Liu, Jiang; Fu, Yingbo; Huang, Xueshi; Wang, Zhanyou. 2009. "Synthesis and Antitumor Activities of Phenanthrene-Based Alkaloids." Molecules 14, no. 12: 5042-5053.