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Molecules 2009, 14(12), 5042-5053; doi:10.3390/molecules14125042

Synthesis and Antitumor Activities of Phenanthrene-Based Alkaloids

1,†, 1,†, 1, 1, 1, 1, 1,*  and 2,*
1 Department of Natural Products Chemistry, Pharmaceutical School, China Medical University, Shenyang 110001, China 2 Laboratory of Cell Engineering and Cell Therapy, College of Basic Medical Science, China Medical University, Shenyang 110001, China These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 26 October 2009 / Revised: 25 November 2009 / Accepted: 2 December 2009 / Published: 7 December 2009
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A series of phenanthrene-based tylophorine derivatives (PBTs) were synthesized and their cytotoxic activities against the H460 human large-cell lung carcinoma cell line were evaluated. Among these compounds, N-(3-hydroxy-2,6,7-tri-methoxyphenanthr-9-ylmethyl)-L-prolinol (5a), and N-(3-hydroxy-2,6,7-trimethoxy-phenanthr-9-ylmethyl)-L-valinol (9) exhibited good activities, with IC50 values of 11.6 and 6.1 mM, respectively.
Keywords: PBTs; synthesis; cytotoxicity PBTs; synthesis; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Li, S.; Han, L.; Sun, L.; Zheng, D.; Liu, J.; Fu, Y.; Huang, X.; Wang, Z. Synthesis and Antitumor Activities of Phenanthrene-Based Alkaloids. Molecules 2009, 14, 5042-5053.

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