Synthesis and Antitumor Activities of Phenanthrene-Based Alkaloids

doi:10.3390/molecules14125042

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Molecules 2009, 14(12), 5042-5053; doi:10.3390/molecules14125042

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Synthesis and Antitumor Activities of Phenanthrene-Based Alkaloids

Songtao Li^1,†, Li Han^1,†, Liang Sun¹, Dan Zheng¹, Jiang Liu¹, Yingbo Fu¹, Xueshi Huang^1,* and Zhanyou Wang^2,*

¹ Department of Natural Products Chemistry, Pharmaceutical School, China Medical University, Shenyang 110001, China ² Laboratory of Cell Engineering and Cell Therapy, College of Basic Medical Science, China Medical University, Shenyang 110001, China ^† These authors contributed equally to this work.

* Authors to whom correspondence should be addressed.

Received: 26 October 2009; in revised form: 25 November 2009 / Accepted: 2 December 2009 / Published: 7 December 2009

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Abstract: A series of phenanthrene-based tylophorine derivatives (PBTs) were synthesized and their cytotoxic activities against the H460 human large-cell lung carcinoma cell line were evaluated. Among these compounds, N-(3-hydroxy-2,6,7-tri-methoxyphenanthr-9-ylmethyl)-L-prolinol (5a), and N-(3-hydroxy-2,6,7-trimethoxy-phenanthr-9-ylmethyl)-L-valinol (9) exhibited good activities, with IC₅₀ values of 11.6 and 6.1 mM, respectively.

Keywords: PBTs; synthesis; cytotoxicity

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MDPI and ACS Style

Li, S.; Han, L.; Sun, L.; Zheng, D.; Liu, J.; Fu, Y.; Huang, X.; Wang, Z. Synthesis and Antitumor Activities of Phenanthrene-Based Alkaloids. Molecules 2009, 14, 5042-5053.

AMA Style

Li S, Han L, Sun L, Zheng D, Liu J, Fu Y, Huang X, Wang Z. Synthesis and Antitumor Activities of Phenanthrene-Based Alkaloids. Molecules. 2009; 14(12):5042-5053.

Chicago/Turabian Style

Li, Songtao; Han, Li; Sun, Liang; Zheng, Dan; Liu, Jiang; Fu, Yingbo; Huang, Xueshi; Wang, Zhanyou. 2009. "Synthesis and Antitumor Activities of Phenanthrene-Based Alkaloids." Molecules 14, no. 12: 5042-5053.

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