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The Effect of Long-Running Severe Selenium-Deficiency on the Amount of Iron and Zinc in the Organs of Rats
Molecules 2009, 14(12), 4880-4891; doi:10.3390/molecules14124880
Review

Selenium Utilization Strategy by Microalgae

 and *
Received: 23 October 2009; in revised form: 18 November 2009 / Accepted: 27 November 2009 / Published: 30 November 2009
(This article belongs to the Special Issue Selenium and Tellurium Chemistry)
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Abstract: The diversity of selenoproteins raises the question of why so many life forms require selenium. Selenoproteins are found in bacteria, archaea, and many eukaryotes. In photosynthetic microorganisms, the essential requirement for selenium has been reported in 33 species belonging to six phyla, although its biochemical significance is still unclear. According to genome databases, 20 species are defined as selenoprotein-producing organisms, including five photosynthetic organisms. In a marine coccolithophorid, Emiliania huxleyi (Haptophyta), we recently found unique characteristics of selenium utilization and novel selenoproteins using 75Se-tracer experiments. In E. huxleyi, selenite, not selenate, is the main substrate used and its uptake is driven by an ATP-dependent highaffinity, active transport system. Selenite is immediately metabolized to low-molecular mass compounds and partly converted to at least six selenoproteins, named EhSEP1–6. The most (EhSEP2) and second-most abundant selenoproteins (EhSEP1) are disulfide isomerase (PDI) homologous protein and thioredoxin reductase (TR) 1, respectively. Involvement of selenium in PDI is unique in this organism, while TR1 is also found in other organisms. In this review, we summarize physiological, biochemical, and molecular aspects of selenium utilization by microalgae and discuss their strategy of selenium utilization.
Keywords: Emiliania huxleyi; selenoprotein; selenite uptake; alga; thioredoxin reductase Emiliania huxleyi; selenoprotein; selenite uptake; alga; thioredoxin reductase
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Araie, H.; Shiraiwa, Y. Selenium Utilization Strategy by Microalgae. Molecules 2009, 14, 4880-4891.

AMA Style

Araie H, Shiraiwa Y. Selenium Utilization Strategy by Microalgae. Molecules. 2009; 14(12):4880-4891.

Chicago/Turabian Style

Araie, Hiroya; Shiraiwa, Yoshihiro. 2009. "Selenium Utilization Strategy by Microalgae." Molecules 14, no. 12: 4880-4891.


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