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• Prachayasittikul, S
• Manam, P
• Chinworrungsee, M
• Isarankura-Na-Ayudhya, C
• Ruchirawat, S
• Prachayasittikul, V
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• Prachayasittikul, S
• Manam, P
• Chinworrungsee, M
• Isarankura-Na-Ayudhya, C
• Ruchirawat, S
• Prachayasittikul, V
• [+] on PubMed
• Prachayasittikul, S
• Manam, P
• Chinworrungsee, M
• Isarankura-Na-Ayudhya, C
• Ruchirawat, S
• Prachayasittikul, V

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Molecules 2009, 14(11), 4414-4424; doi:10.3390/molecules14114414

Article

Bioactive Azafluorenone Alkaloids from Polyalthia debilis (Pierre) Finet & Gagnep.

Supaluk Prachayasittikul ^1,* , Patumporn Manam ¹ , Maneekarn Chinworrungsee ¹ , Chartchalerm Isarankura-Na-Ayudhya ² , Somsak Ruchirawat ³  and Virapong Prachayasittikul ^2,*

¹ Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok 10110, Thailand ² Department of Clinical Microbiology, Faculty of Medical Technology, Mahidol University, Bangkok 10700 , Thailand ³ Chulabhorn Research Institute and Chulabhorn Graduate Institute, Bangkok 10210, Thailand

* Authors to whom correspondence should be addressed.

Received: 15 September 2009; in revised form: 21 October 2009 / Accepted: 2 November 2009 / Published: 3 November 2009

Download PDF Full-Text [268 KB, uploaded 4 November 2009 14:14 CET]

Abstract: This study investigated bioactive extracts of Polyalthia debilis (Annonaceae) with antimicrobial, antimalarial and cytotoxic activities. Extensive chromatographic isolations provided azafluorenone alkaloids; onychine (1) and 7-methoxyonychine (2) together with a mixture of β–sitosterol and stigmasterol. The two alkaloids were isolated from the P. debilis for the first time. Isolated fractions containing a mixture of triterpenoids (C7, C8 and C9) exhibited the most potent antimicrobial activity against many bacterial strains with minimum inhibitory concentration of 64 μg/mL. Fractions with antimalarial and cytotoxic activities were also observed. The findings suggest the potential use of P. debilis in medicinal applications.

Keywords: Polyalthia debilis; azafluorenone; onychine; antimicrobial; antimalarial and cytotoxic activities

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