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Bioactive Azafluorenone Alkaloids from Polyalthia debilis (Pierre) Finet & Gagnep.
Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok 10110, Thailand
Department of Clinical Microbiology, Faculty of Medical Technology, Mahidol University, Bangkok 10700 , Thailand
Chulabhorn Research Institute and Chulabhorn Graduate Institute, Bangkok 10210, Thailand
* Authors to whom correspondence should be addressed.
Received: 15 September 2009; in revised form: 21 October 2009 / Accepted: 2 November 2009 / Published: 3 November 2009
Abstract: This study investigated bioactive extracts of Polyalthia debilis (Annonaceae) with antimicrobial, antimalarial and cytotoxic activities. Extensive chromatographic isolations provided azafluorenone alkaloids; onychine (1) and 7-methoxyonychine (2) together with a mixture of β–sitosterol and stigmasterol. The two alkaloids were isolated from the P. debilis for the first time. Isolated fractions containing a mixture of triterpenoids (C7, C8 and C9) exhibited the most potent antimicrobial activity against many bacterial strains with minimum inhibitory concentration of 64 μg/mL. Fractions with antimalarial and cytotoxic activities were also observed. The findings suggest the potential use of P. debilis in medicinal applications.
Keywords: Polyalthia debilis; azafluorenone; onychine; antimicrobial; antimalarial and cytotoxic activities
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Prachayasittikul, S.; Manam, P.; Chinworrungsee, M.; Isarankura-Na-Ayudhya, C.; Ruchirawat, S.; Prachayasittikul, V. Bioactive Azafluorenone Alkaloids from Polyalthia debilis (Pierre) Finet & Gagnep.. Molecules 2009, 14, 4414-4424.
Prachayasittikul S, Manam P, Chinworrungsee M, Isarankura-Na-Ayudhya C, Ruchirawat S, Prachayasittikul V. Bioactive Azafluorenone Alkaloids from Polyalthia debilis (Pierre) Finet & Gagnep.. Molecules. 2009; 14(11):4414-4424.
Prachayasittikul, Supaluk; Manam, Patumporn; Chinworrungsee, Maneekarn; Isarankura-Na-Ayudhya, Chartchalerm; Ruchirawat, Somsak; Prachayasittikul, Virapong. 2009. "Bioactive Azafluorenone Alkaloids from Polyalthia debilis (Pierre) Finet & Gagnep.." Molecules 14, no. 11: 4414-4424.