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Molecules 2009, 14(11), 4414-4424; doi:10.3390/molecules14114414
Article

Bioactive Azafluorenone Alkaloids from Polyalthia debilis (Pierre) Finet & Gagnep.

1,* , 1, 1, 2, 3 and 2,*
Received: 15 September 2009; in revised form: 21 October 2009 / Accepted: 2 November 2009 / Published: 3 November 2009
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Abstract: This study investigated bioactive extracts of Polyalthia debilis (Annonaceae) with antimicrobial, antimalarial and cytotoxic activities. Extensive chromatographic isolations provided azafluorenone alkaloids; onychine (1) and 7-methoxyonychine (2) together with a mixture of β–sitosterol and stigmasterol. The two alkaloids were isolated from the P. debilis for the first time. Isolated fractions containing a mixture of triterpenoids (C7, C8 and C9) exhibited the most potent antimicrobial activity against many bacterial strains with minimum inhibitory concentration of 64 μg/mL. Fractions with antimalarial and cytotoxic activities were also observed. The findings suggest the potential use of P. debilis in medicinal applications.
Keywords: Polyalthia debilis; azafluorenone; onychine; antimicrobial; antimalarial and cytotoxic activities Polyalthia debilis; azafluorenone; onychine; antimicrobial; antimalarial and cytotoxic activities
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Prachayasittikul, S.; Manam, P.; Chinworrungsee, M.; Isarankura-Na-Ayudhya, C.; Ruchirawat, S.; Prachayasittikul, V. Bioactive Azafluorenone Alkaloids from Polyalthia debilis (Pierre) Finet & Gagnep.. Molecules 2009, 14, 4414-4424.

AMA Style

Prachayasittikul S, Manam P, Chinworrungsee M, Isarankura-Na-Ayudhya C, Ruchirawat S, Prachayasittikul V. Bioactive Azafluorenone Alkaloids from Polyalthia debilis (Pierre) Finet & Gagnep.. Molecules. 2009; 14(11):4414-4424.

Chicago/Turabian Style

Prachayasittikul, Supaluk; Manam, Patumporn; Chinworrungsee, Maneekarn; Isarankura-Na-Ayudhya, Chartchalerm; Ruchirawat, Somsak; Prachayasittikul, Virapong. 2009. "Bioactive Azafluorenone Alkaloids from Polyalthia debilis (Pierre) Finet & Gagnep.." Molecules 14, no. 11: 4414-4424.


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