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A New Atisane-Type Diterpene from the Bark of the Mangrove Plant Excoecaria Agallocha
Key Laboratory of Ministry of Education for Coastal and Wetland Ecosystems, School of Life Sciences, Xiamen University, Xiamen 361005, China
College of Oceanography and Environmental Science, Xiamen University, Xiamen 361005, China
The Third Institute of Oceanography State Oceanic Administration, Xiamen 361005, China
* Author to whom correspondence should be addressed.
Received: 26 October 2008; in revised form: 13 January 2009 / Accepted: 15 January 2009 / Published: 16 January 2009
Abstract: A new atisane-type diterpene, ent-16α-hydroxy-atisane-3,4-lactone (4) and three known diterpenes, ent-16α-hydroxy-atisane-3-one (1), ent-atisane-3β,16α-diol (2), ent-3,4-seco-16α-hydroxyatis- 4(19)-en -3-oic acid (3) were isolated from the bark of the mangrove plant Excoecaria agallocha. Their structures and relative stereochemistry were elucidated by means of extensive NMR and MS analysis. Compound 3 exhibited significant anti-microfouling activity against the adherence of Pseudomonas pseudoalcaligenes, with an EC50 value of 0.54 ± 0.01 ppm.
Keywords: Diterpenes; Biofilm; Excoecaria agallocha; Anti-microfouling
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Wang, Z.C.; Lin, Y.M.; Feng, D.Q.; Ke, C.H.; Lin, P.; Yan, C.L.; Chen, J.D. A New Atisane-Type Diterpene from the Bark of the Mangrove Plant Excoecaria Agallocha. Molecules 2009, 14, 414-422.
Wang ZC, Lin YM, Feng DQ, Ke CH, Lin P, Yan CL, Chen JD. A New Atisane-Type Diterpene from the Bark of the Mangrove Plant Excoecaria Agallocha. Molecules. 2009; 14(1):414-422.
Wang, Zhan Chang; Lin, Yi Ming; Feng, Dan Qin; Ke, Cai Huan; Lin, Peng; Yan, Chong Ling; Chen, Jun De. 2009. "A New Atisane-Type Diterpene from the Bark of the Mangrove Plant Excoecaria Agallocha." Molecules 14, no. 1: 414-422.