A New Atisane-Type Diterpene from the Bark of the Mangrove Plant Excoecaria Agallocha

doi:10.3390/molecules14010414

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Molecules 2009, 14(1), 414-422; doi:10.3390/molecules14010414

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A New Atisane-Type Diterpene from the Bark of the Mangrove Plant Excoecaria Agallocha

Zhan Chang Wang¹, Yi Ming Lin^1,* , Dan Qin Feng², Cai Huan Ke², Peng Lin¹, Chong Ling Yan¹ and Jun De Chen³

¹ Key Laboratory of Ministry of Education for Coastal and Wetland Ecosystems, School of Life Sciences, Xiamen University, Xiamen 361005, China ² College of Oceanography and Environmental Science, Xiamen University, Xiamen 361005, China ³ The Third Institute of Oceanography State Oceanic Administration, Xiamen 361005, China

* Author to whom correspondence should be addressed.

Received: 26 October 2008; in revised form: 13 January 2009 / Accepted: 15 January 2009 / Published: 16 January 2009

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Abstract: A new atisane-type diterpene, ent-16α-hydroxy-atisane-3,4-lactone (4) and three known diterpenes, ent-16α-hydroxy-atisane-3-one (1), ent-atisane-3β,16α-diol (2), ent-3,4-seco-16α-hydroxyatis- 4(19)-en -3-oic acid (3) were isolated from the bark of the mangrove plant Excoecaria agallocha. Their structures and relative stereochemistry were elucidated by means of extensive NMR and MS analysis. Compound 3 exhibited significant anti-microfouling activity against the adherence of Pseudomonas pseudoalcaligenes, with an EC₅₀ value of 0.54 ± 0.01 ppm.

Keywords: Diterpenes; Biofilm; Excoecaria agallocha; Anti-microfouling

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Cite This Article

MDPI and ACS Style

Wang, Z.C.; Lin, Y.M.; Feng, D.Q.; Ke, C.H.; Lin, P.; Yan, C.L.; Chen, J.D. A New Atisane-Type Diterpene from the Bark of the Mangrove Plant Excoecaria Agallocha. Molecules 2009, 14, 414-422.

AMA Style

Wang Z.C., Lin Y.M., Feng D.Q., Ke C.H., Lin P., Yan C.L., Chen J.D. A New Atisane-Type Diterpene from the Bark of the Mangrove Plant Excoecaria Agallocha. Molecules. 2009; 14(1):414-422.

Chicago/Turabian Style

Wang, Zhan Chang; Lin, Yi Ming; Feng, Dan Qin; Ke, Cai Huan; Lin, Peng; Yan, Chong Ling; Chen, Jun De. 2009. "A New Atisane-Type Diterpene from the Bark of the Mangrove Plant Excoecaria Agallocha." Molecules 14, no. 1: 414-422.

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