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Molecular Docking Studies and Anti-Tyrosinase Activity of Thai Mango Seed Kernel Extract
Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand
Department of Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10300, Thailand
Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand
* Author to whom correspondence should be addressed.
Received: 16 November 2008; in revised form: 18 December 2008 / Accepted: 4 January 2009 / Published: 7 January 2009
Abstract: The alcoholic extract from seed kernels of Thai mango (Mangifera indica L. cv. ‘Fahlun’) (Anacardiaceae) and its major phenolic principle (pentagalloylglucopyranose) exhibited potent, dose-dependent inhibitory effects on tyrosinase with respect to L-DOPA. Molecular docking studies revealed that the binding orientations of the phenolic principles were in the tyrosinase binding pocket and their orientations were located in the hydrophobic binding pocket surrounding the binuclear copper active site. The results indicated a possible mechanism for their anti-tyrosinase activity which may involve an ability to chelate the copper atoms which are required for the catalytic activity of tyrosinase.
Keywords: Mangifera indica L; Molecular docking study; Polyphenols; Pentagalloylglucopyranose; Tyrosinase inhibitor
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Nithitanakool, S.; Pithayanukul, P.; Bavovada, R.; Saparpakorn, P. Molecular Docking Studies and Anti-Tyrosinase Activity of Thai Mango Seed Kernel Extract. Molecules 2009, 14, 257-265.
Nithitanakool S, Pithayanukul P, Bavovada R, Saparpakorn P. Molecular Docking Studies and Anti-Tyrosinase Activity of Thai Mango Seed Kernel Extract. Molecules. 2009; 14(1):257-265.
Nithitanakool, Saruth; Pithayanukul, Pimolpan; Bavovada, Rapepol; Saparpakorn, Patchreenart. 2009. "Molecular Docking Studies and Anti-Tyrosinase Activity of Thai Mango Seed Kernel Extract." Molecules 14, no. 1: 257-265.