Next Article in Journal
Synthesis of 2,3-Dioxo-5-(substituted)arylpyrroles and Their 2-Oxo-5-aryl-3-hydrazone Pyrrolidine Derivatives
Next Article in Special Issue
Antioxidant Phenolic Substances of Turkish Red Wines from Different Wine Regions
Previous Article in Journal
The Use of Coumarins as Environmentally-Sensitive Fluorescent Probes of Heterogeneous Inclusion Systems
Previous Article in Special Issue
Phenolic and Theobromine Contents of Commercial Dark, Milk and White Chocolates on the Malaysian Market
Article Menu

Export Article

Open AccessArticle
Molecules 2009, 14(1), 257-265; doi:10.3390/molecules14010257

Molecular Docking Studies and Anti-Tyrosinase Activity of Thai Mango Seed Kernel Extract

1
Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand
2
Department of Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10300, Thailand
3
Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand
*
Author to whom correspondence should be addressed.
Received: 16 November 2008 / Revised: 18 December 2008 / Accepted: 4 January 2009 / Published: 7 January 2009
(This article belongs to the Special Issue Phenolics and Polyphenolics)
View Full-Text   |   Download PDF [595 KB, uploaded 18 June 2014]   |  

Abstract

The alcoholic extract from seed kernels of Thai mango (Mangifera indica L. cv. ‘Fahlun’) (Anacardiaceae) and its major phenolic principle (pentagalloylglucopyranose) exhibited potent, dose-dependent inhibitory effects on tyrosinase with respect to L-DOPA. Molecular docking studies revealed that the binding orientations of the phenolic principles were in the tyrosinase binding pocket and their orientations were located in the hydrophobic binding pocket surrounding the binuclear copper active site. The results indicated a possible mechanism for their anti-tyrosinase activity which may involve an ability to chelate the copper atoms which are required for the catalytic activity of tyrosinase. View Full-Text
Keywords: Mangifera indica L; Molecular docking study; Polyphenols; Pentagalloylglucopyranose; Tyrosinase inhibitor Mangifera indica L; Molecular docking study; Polyphenols; Pentagalloylglucopyranose; Tyrosinase inhibitor
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Nithitanakool, S.; Pithayanukul, P.; Bavovada, R.; Saparpakorn, P. Molecular Docking Studies and Anti-Tyrosinase Activity of Thai Mango Seed Kernel Extract. Molecules 2009, 14, 257-265.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top