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Molecules 2009, 14(1), 257-265; doi:10.3390/molecules14010257
Article

Molecular Docking Studies and Anti-Tyrosinase Activity of Thai Mango Seed Kernel Extract

1
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1,* , 2
 and
3
Received: 16 November 2008 / Revised: 18 December 2008 / Accepted: 4 January 2009 / Published: 7 January 2009
(This article belongs to the Special Issue Phenolics and Polyphenolics)
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Abstract

The alcoholic extract from seed kernels of Thai mango (Mangifera indica L. cv. ‘Fahlun’) (Anacardiaceae) and its major phenolic principle (pentagalloylglucopyranose) exhibited potent, dose-dependent inhibitory effects on tyrosinase with respect to L-DOPA. Molecular docking studies revealed that the binding orientations of the phenolic principles were in the tyrosinase binding pocket and their orientations were located in the hydrophobic binding pocket surrounding the binuclear copper active site. The results indicated a possible mechanism for their anti-tyrosinase activity which may involve an ability to chelate the copper atoms which are required for the catalytic activity of tyrosinase.
Keywords: Mangifera indica L; Molecular docking study; Polyphenols; Pentagalloylglucopyranose; Tyrosinase inhibitor Mangifera indica L; Molecular docking study; Polyphenols; Pentagalloylglucopyranose; Tyrosinase inhibitor
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Nithitanakool, S.; Pithayanukul, P.; Bavovada, R.; Saparpakorn, P. Molecular Docking Studies and Anti-Tyrosinase Activity of Thai Mango Seed Kernel Extract. Molecules 2009, 14, 257-265.

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