Next Article in Journal
Next Article in Special Issue
Previous Article in Journal
Previous Article in Special Issue
Molecules 2009, 14(1), 257-265; doi:10.3390/molecules14010257
Article

Molecular Docking Studies and Anti-Tyrosinase Activity of Thai Mango Seed Kernel Extract

1
, 1,* , 2
 and 3
Received: 16 November 2008; in revised form: 18 December 2008 / Accepted: 4 January 2009 / Published: 7 January 2009
(This article belongs to the Special Issue Phenolics and Polyphenolics)
Download PDF [595 KB, uploaded 18 June 2014]
Abstract: The alcoholic extract from seed kernels of Thai mango (Mangifera indica L. cv. ‘Fahlun’) (Anacardiaceae) and its major phenolic principle (pentagalloylglucopyranose) exhibited potent, dose-dependent inhibitory effects on tyrosinase with respect to L-DOPA. Molecular docking studies revealed that the binding orientations of the phenolic principles were in the tyrosinase binding pocket and their orientations were located in the hydrophobic binding pocket surrounding the binuclear copper active site. The results indicated a possible mechanism for their anti-tyrosinase activity which may involve an ability to chelate the copper atoms which are required for the catalytic activity of tyrosinase.
Keywords: Mangifera indica L; Molecular docking study; Polyphenols; Pentagalloylglucopyranose; Tyrosinase inhibitor Mangifera indica L; Molecular docking study; Polyphenols; Pentagalloylglucopyranose; Tyrosinase inhibitor
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Nithitanakool, S.; Pithayanukul, P.; Bavovada, R.; Saparpakorn, P. Molecular Docking Studies and Anti-Tyrosinase Activity of Thai Mango Seed Kernel Extract. Molecules 2009, 14, 257-265.

AMA Style

Nithitanakool S, Pithayanukul P, Bavovada R, Saparpakorn P. Molecular Docking Studies and Anti-Tyrosinase Activity of Thai Mango Seed Kernel Extract. Molecules. 2009; 14(1):257-265.

Chicago/Turabian Style

Nithitanakool, Saruth; Pithayanukul, Pimolpan; Bavovada, Rapepol; Saparpakorn, Patchreenart. 2009. "Molecular Docking Studies and Anti-Tyrosinase Activity of Thai Mango Seed Kernel Extract." Molecules 14, no. 1: 257-265.


Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert