5-Fluorouracil: Mechanisms of Resistance and Reversal Strategies

doi:10.3390/molecules13081551

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Molecules 2008, 13(8), 1551-1569; doi:10.3390/molecules13081551

Review

5-Fluorouracil: Mechanisms of Resistance and Reversal Strategies

Ning Zhang ¹ , Ying Yin ² , Sheng-Jie Xu ² and Wei-Shan Chen ¹^,*

¹ Department of Orthopaedics, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, #88 Jiefang Road, Hangzhou, 310009, P.R. China ² Institute of Clinical Research, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, #3 East Qingchun Road, Hangzhou, 310016, P.R. China

* Author to whom correspondence should be addressed.

Received: 18 June 2008; in revised form: 1 July 2008 / Accepted: 15 July 2008 / Published: 5 August 2008

(This article belongs to the Special Issue 5-Fluorouracil)

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Abstract: The purpose of this work is to review the published studies on the mechanisms of action and resistance of 5-fluorouracil. The review is divided into three main sections: mechanisms of anti-tumor action, studies of the resistance to the drug, and procedures for the identification of new genes involved in resistance with microarray techniques. The details of the induction and reversal of the drug resistance are also described.

Keywords: 5-Fluorouracil; mechanism; resistance; microarray; therapeutic strategies

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Cite This Article

MDPI and ACS Style

Zhang, N.; Yin, Y.; Xu, S.-J.; Chen, W.-S. 5-Fluorouracil: Mechanisms of Resistance and Reversal Strategies. Molecules 2008, 13, 1551-1569.

AMA Style

Zhang N., Yin Y., Xu S.-J., Chen W.-S. 5-Fluorouracil: Mechanisms of Resistance and Reversal Strategies. Molecules. 2008; 13(8):1551-1569.

Chicago/Turabian Style

Zhang, Ning; Yin, Ying; Xu, Sheng-Jie; Chen, Wei-Shan. 2008. "5-Fluorouracil: Mechanisms of Resistance and Reversal Strategies." Molecules 13, no. 8: 1551-1569.

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