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Molecules 2008, 13(8), 1530-1537; doi:10.3390/molecules13081530
Article

Isolation and Characterization of Phenolic Compounds from the Leaves of Salix matsudana

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Received: 2 July 2008 / Revised: 31 July 2008 / Accepted: 31 July 2008 / Published: 3 August 2008
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Abstract

A bioassay-guided in vitro screen has revealed that a 70% methanol extract of the leaves of Salix matsudana shows considerable inhibitory activity against cyclooxygenases (COX-1 and COX-2). A subsequent phytochemical study led to the isolation of a new flavonoid, matsudone A (1), together with five known flavonoids – luteolin (2), isoquercitrin (3), 7-methoxyflavone (4), luteolin 7-O-glucoside (5), 4',7-dihydroxyflavone (6) – and two phenolic glycosides, leonuriside A (7) and piceoside (8). Their structures were elucidated on the basis of extensive 1D- and 2D-NMR studies, high resolution ESI mass spectroscopic analyses and comparisons with literature data. The isolated compounds 1-8 were tested for their inhibitory activities against COX-1 and COX-2. Compounds 1, 5 and 6 were found to have potent inhibitory effect on COX-2 and compounds 3-5 exhibited moderate inhibition against COX-1.
Keywords: Salix matsudana; matsudone A; flavonoid; cyclooxygenase inhibition. Salix matsudana; matsudone A; flavonoid; cyclooxygenase inhibition.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Li, X.; Liu, Z.; Zhang, X.-F.; Wang, L.-J.; Zheng, Y.-N.; Yuan, C.-C.; Sun, G.-Z. Isolation and Characterization of Phenolic Compounds from the Leaves of Salix matsudana. Molecules 2008, 13, 1530-1537.

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