Next Article in Journal
Structure Determination of β-Glucans from Ganoderma lucidum with Matrix-assisted Laser Desorption/ionization (MALDI) Mass Spectrometry
Previous Article in Journal
HPLC-ESI-MS/MS of Imidazole Alkaloids in Pilocarpus microphyllus
Molecules 2008, 13(8), 1530-1537; doi:10.3390/molecules13081530

Isolation and Characterization of Phenolic Compounds from the Leaves of Salix matsudana

Received: 2 July 2008 / Revised: 31 July 2008 / Accepted: 31 July 2008 / Published: 3 August 2008
Download PDF [194 KB, uploaded 18 June 2014]


A bioassay-guided in vitro screen has revealed that a 70% methanol extract of the leaves of Salix matsudana shows considerable inhibitory activity against cyclooxygenases (COX-1 and COX-2). A subsequent phytochemical study led to the isolation of a new flavonoid, matsudone A (1), together with five known flavonoids – luteolin (2), isoquercitrin (3), 7-methoxyflavone (4), luteolin 7-O-glucoside (5), 4',7-dihydroxyflavone (6) – and two phenolic glycosides, leonuriside A (7) and piceoside (8). Their structures were elucidated on the basis of extensive 1D- and 2D-NMR studies, high resolution ESI mass spectroscopic analyses and comparisons with literature data. The isolated compounds 1-8 were tested for their inhibitory activities against COX-1 and COX-2. Compounds 1, 5 and 6 were found to have potent inhibitory effect on COX-2 and compounds 3-5 exhibited moderate inhibition against COX-1.
Keywords: Salix matsudana; matsudone A; flavonoid; cyclooxygenase inhibition. Salix matsudana; matsudone A; flavonoid; cyclooxygenase inhibition.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Li, X.; Liu, Z.; Zhang, X.-F.; Wang, L.-J.; Zheng, Y.-N.; Yuan, C.-C.; Sun, G.-Z. Isolation and Characterization of Phenolic Compounds from the Leaves of Salix matsudana. Molecules 2008, 13, 1530-1537.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert