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Molecules 2008, 13(8), 1530-1537; doi:10.3390/molecules13081530
Article

Isolation and Characterization of Phenolic Compounds from the Leaves of Salix matsudana

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1 College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, P.R. China 2 Present address: Agriculture and Agri-Food Canada, Saskatoon Research Center, 107 Science Place, Saskatoon, SK, S7N_0X2, Canada 3 Institute of Agricultural Modernization, Jilin Agricultural University, Changchun, 130118, P.R. China 4 College of Forestry and Biotechnology, Zhejiang Forestry University, Hangzhou, 311300, P.R. China
* Author to whom correspondence should be addressed.
Received: 2 July 2008 / Revised: 31 July 2008 / Accepted: 31 July 2008 / Published: 3 August 2008
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Abstract

A bioassay-guided in vitro screen has revealed that a 70% methanol extract of the leaves of Salix matsudana shows considerable inhibitory activity against cyclooxygenases (COX-1 and COX-2). A subsequent phytochemical study led to the isolation of a new flavonoid, matsudone A (1), together with five known flavonoids – luteolin (2), isoquercitrin (3), 7-methoxyflavone (4), luteolin 7-O-glucoside (5), 4',7-dihydroxyflavone (6) – and two phenolic glycosides, leonuriside A (7) and piceoside (8). Their structures were elucidated on the basis of extensive 1D- and 2D-NMR studies, high resolution ESI mass spectroscopic analyses and comparisons with literature data. The isolated compounds 1-8 were tested for their inhibitory activities against COX-1 and COX-2. Compounds 1, 5 and 6 were found to have potent inhibitory effect on COX-2 and compounds 3-5 exhibited moderate inhibition against COX-1.
Keywords: Salix matsudana; matsudone A; flavonoid; cyclooxygenase inhibition. Salix matsudana; matsudone A; flavonoid; cyclooxygenase inhibition.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Li, X.; Liu, Z.; Zhang, X.-F.; Wang, L.-J.; Zheng, Y.-N.; Yuan, C.-C.; Sun, G.-Z. Isolation and Characterization of Phenolic Compounds from the Leaves of Salix matsudana. Molecules 2008, 13, 1530-1537.

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