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Molecules 2008, 13(6), 1275-1281; doi:10.3390/molecules13061275

A New Sesquiterpenoid Hydroquinone from the Marine Sponge Dysidea arenaria

*  and
Department of Pharmacy, School of Medical, Xiamen University, Xiamen 361005, People’s Republic of China
* Author to whom correspondence should be addressed.
Received: 23 May 2008 / Revised: 5 June 2008 / Accepted: 5 June 2008 / Published: 6 June 2008
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Detailed chemical investigation of the South China sponge Dysidea arenaria resulted in the isolation of a new sesquiterpenoid hydroquinone, 19-hydroxypolyfibrospongol B (1), along with five known compounds: polyfibrospongol B (2), isosemnonorthoquinone (3), ilimaquinone (4), smenospongine (5) and smenotronic acid (6). The structures were determined by extensive spectroscopic analysis. The in vitro anti- HIV activity on HIV-1 RT was evaluated. Compounds 3 -6 displayed moderate inhibitory activity, with IC50 values of 239.7, 16.4, 176.1, and 130.4 μM, respectively, while 1 and 2 were found to be inactive against the same biological target.
Keywords: Sesquiterpenoid hydroquinone; anti-HIV activity; Dysidea arenaria. Sesquiterpenoid hydroquinone; anti-HIV activity; Dysidea arenaria.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Qiu, Y.; Wang, X.M. A New Sesquiterpenoid Hydroquinone from the Marine Sponge Dysidea arenaria. Molecules 2008, 13, 1275-1281.

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