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Molecules 2008, 13(6), 1275-1281; doi:10.3390/molecules13061275

A New Sesquiterpenoid Hydroquinone from the Marine Sponge Dysidea arenaria

*  and
Department of Pharmacy, School of Medical, Xiamen University, Xiamen 361005, People’s Republic of China
* Author to whom correspondence should be addressed.
Received: 23 May 2008 / Revised: 5 June 2008 / Accepted: 5 June 2008 / Published: 6 June 2008
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Detailed chemical investigation of the South China sponge Dysidea arenaria resulted in the isolation of a new sesquiterpenoid hydroquinone, 19-hydroxypolyfibrospongol B (1), along with five known compounds: polyfibrospongol B (2), isosemnonorthoquinone (3), ilimaquinone (4), smenospongine (5) and smenotronic acid (6). The structures were determined by extensive spectroscopic analysis. The in vitro anti- HIV activity on HIV-1 RT was evaluated. Compounds 3 -6 displayed moderate inhibitory activity, with IC50 values of 239.7, 16.4, 176.1, and 130.4 μM, respectively, while 1 and 2 were found to be inactive against the same biological target.
Keywords: Sesquiterpenoid hydroquinone; anti-HIV activity; Dysidea arenaria. Sesquiterpenoid hydroquinone; anti-HIV activity; Dysidea arenaria.
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Qiu, Y.; Wang, X.M. A New Sesquiterpenoid Hydroquinone from the Marine Sponge Dysidea arenaria. Molecules 2008, 13, 1275-1281.

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