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Molecules 2008, 13(4), 779-789; doi:10.3390/molecules13040779
Article

A Microwave-Assisted and Heteropolyacids-Catalysed Cyclocondensation Reaction for the Synthesis of 4(3H)-Quinazolinones

1, 1, 2, 2, 1 and 3,*
1 Laboratoire de Chimie Organique Appliquée (Equipe Hétérocycles Associée CRAPC). Faculté de Chimie. Université des Sciences et de la Technologie Houari Boumediène. BP 32, El-Alia. 16111 Bab-Ezzouar. Alger, Algeria 2 Laboratoire de Chimie du Gaz Naturel. Faculté de Chimie. Université des Sciences et de la Technologie Houari Boumediène. BP 32, El-Alia. 16111 Bab-Ezzouar. Alger, Algeria 3 Laboratoire de Biochimie-Purpan, Institut Fédératif de Biologie, CHU Toulouse 330, Avenue de Grande-Bretagne – F- 31059 Toulouse cedex 9, France
* Author to whom correspondence should be addressed.
Received: 6 February 2008 / Revised: 28 March 2008 / Accepted: 28 March 2008 / Published: 3 April 2008
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Abstract

We have investigated a microwave–assisted synthesis of 4(3H)–quinazolinonesby condensation of anthranilic acid, orthoesters (or formic acid) and substituted anilines,using Keggin-type heteropolyacids (H3PW12O40·13H2O, H4SiW12O40·13H2O,H4SiMo12O40·13H2O or H3PMo12O40·13H2O) as catalysts. We found that the the use of H3PW12O40·13H2O acid coupled to microwave irradiation allows a solvent-free, rapid (~ 13min) and high-yielding reaction.
Keywords: 4(3H)–Quinazolinones; heteropolyacids; microwave irradiation; solvent-free synthesis 4(3H)–Quinazolinones; heteropolyacids; microwave irradiation; solvent-free synthesis
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Ighilahriz, K.; Boutemeur, B.; Chami, F.; Rabia, C.; Hamdi, M.; Hamdi, S.M. A Microwave-Assisted and Heteropolyacids-Catalysed Cyclocondensation Reaction for the Synthesis of 4(3H)-Quinazolinones. Molecules 2008, 13, 779-789.

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