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Molecules 2008, 13(4), 779-789; doi:10.3390/molecules13040779

A Microwave-Assisted and Heteropolyacids-Catalysed Cyclocondensation Reaction for the Synthesis of 4(3H)-Quinazolinones

1
Laboratoire de Chimie Organique Appliquée (Equipe Hétérocycles Associée CRAPC). Faculté de Chimie. Université des Sciences et de la Technologie Houari Boumediène. BP 32, El-Alia. 16111 Bab-Ezzouar. Alger, Algeria
2
Laboratoire de Chimie du Gaz Naturel. Faculté de Chimie. Université des Sciences et de la Technologie Houari Boumediène. BP 32, El-Alia. 16111 Bab-Ezzouar. Alger, Algeria
3
Laboratoire de Biochimie-Purpan, Institut Fédératif de Biologie, CHU Toulouse 330, Avenue de Grande-Bretagne – F- 31059 Toulouse cedex 9, France
*
Author to whom correspondence should be addressed.
Received: 6 February 2008 / Revised: 28 March 2008 / Accepted: 28 March 2008 / Published: 3 April 2008
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Abstract

We have investigated a microwave–assisted synthesis of 4(3H)–quinazolinonesby condensation of anthranilic acid, orthoesters (or formic acid) and substituted anilines,using Keggin-type heteropolyacids (H3PW12O40·13H2O, H4SiW12O40·13H2O,H4SiMo12O40·13H2O or H3PMo12O40·13H2O) as catalysts. We found that the the use of H3PW12O40·13H2O acid coupled to microwave irradiation allows a solvent-free, rapid (~ 13min) and high-yielding reaction.
Keywords: 4(3H)–Quinazolinones; heteropolyacids; microwave irradiation; solvent-free synthesis 4(3H)–Quinazolinones; heteropolyacids; microwave irradiation; solvent-free synthesis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Ighilahriz, K.; Boutemeur, B.; Chami, F.; Rabia, C.; Hamdi, M.; Hamdi, S.M. A Microwave-Assisted and Heteropolyacids-Catalysed Cyclocondensation Reaction for the Synthesis of 4(3H)-Quinazolinones. Molecules 2008, 13, 779-789.

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