Molecules 2008, 13(4), 779-789; doi:10.3390/molecules13040779
Article

A Microwave-Assisted and Heteropolyacids-Catalysed Cyclocondensation Reaction for the Synthesis of 4(3H)-Quinazolinones

Received: 6 February 2008; in revised form: 28 March 2008 / Accepted: 28 March 2008 / Published: 3 April 2008
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: We have investigated a microwave–assisted synthesis of 4(3H)–quinazolinonesby condensation of anthranilic acid, orthoesters (or formic acid) and substituted anilines,using Keggin-type heteropolyacids (H3PW12O40·13H2O, H4SiW12O40·13H2O,H4SiMo12O40·13H2O or H3PMo12O40·13H2O) as catalysts. We found that the the use of H3PW12O40·13H2O acid coupled to microwave irradiation allows a solvent-free, rapid (~ 13min) and high-yielding reaction.
Keywords: 4(3H)–Quinazolinones; heteropolyacids; microwave irradiation; solvent-free synthesis
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MDPI and ACS Style

Ighilahriz, K.; Boutemeur, B.; Chami, F.; Rabia, C.; Hamdi, M.; Hamdi, S.M. A Microwave-Assisted and Heteropolyacids-Catalysed Cyclocondensation Reaction for the Synthesis of 4(3H)-Quinazolinones. Molecules 2008, 13, 779-789.

AMA Style

Ighilahriz K, Boutemeur B, Chami F, Rabia C, Hamdi M, Hamdi SM. A Microwave-Assisted and Heteropolyacids-Catalysed Cyclocondensation Reaction for the Synthesis of 4(3H)-Quinazolinones. Molecules. 2008; 13(4):779-789.

Chicago/Turabian Style

Ighilahriz, Karima; Boutemeur, Baya; Chami, Fariza; Rabia, Cherifa; Hamdi, Maâmar; Hamdi, Safouane M. 2008. "A Microwave-Assisted and Heteropolyacids-Catalysed Cyclocondensation Reaction for the Synthesis of 4(3H)-Quinazolinones." Molecules 13, no. 4: 779-789.

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