Molecules 2008, 13(3), 595-602; doi:10.3390/molecules13030595
Communication

Cytotoxic Metabolites from the Okinawan Ascidian Diplosoma virens

1,2email, 3email, 1 and 1,* email
Received: 20 February 2008; in revised form: 8 March 2008 / Accepted: 9 March 2008 / Published: 11 March 2008
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The unstable isomeric compounds 5-hydroxy-7-prop-2-en-(E)-ylidene-7,7adihydro-2H-cyclopenta[b]pyran-6-one (1) and 5-hydroxy-7-prop-2-en-(Z)-ylidene-7,7adihydro-2H-cyclopenta[b]pyran-6-one (2), previously described as antimicrobialmetabolites from the sponge Ulosa sp., were isolated and identified as major componentsof the ascidian Diplosoma virens. In this paper, full spectral data for 2 and complete 13CNMRdata for 1, based on 2D NMR measurements, are provided for the first time.Compounds 1 and 2 showed cytotoxity against HCT116 cells (human colorectal cancercells) by triggering apoptotic cell death.
Keywords: Diplosoma virens; HCT116; apoptosis; NMR
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MDPI and ACS Style

Ogi, T.; Taira, J.; Margiastuti, P.; Ueda, K. Cytotoxic Metabolites from the Okinawan Ascidian Diplosoma virens. Molecules 2008, 13, 595-602.

AMA Style

Ogi T, Taira J, Margiastuti P, Ueda K. Cytotoxic Metabolites from the Okinawan Ascidian Diplosoma virens. Molecules. 2008; 13(3):595-602.

Chicago/Turabian Style

Ogi, Takayuki; Taira, Junsei; Margiastuti, Palupi; Ueda, Katsuhiro. 2008. "Cytotoxic Metabolites from the Okinawan Ascidian Diplosoma virens." Molecules 13, no. 3: 595-602.

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