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Cytotoxic Metabolites from the Okinawan Ascidian Diplosoma virens
Department of Chemistry, Biology and Marine Science, University of the Ryukyus, Nishihara-cho Okinawa 903-0123, Japan
Okinawa Industrial Technology Center, Uruma-shi Okinawa 904-2234, Japan
Department of Bioresources Engineering, Okinawa National College of Technology, Nago-shi Okinawa 905-2192, Japan
* Author to whom correspondence should be addressed.
Received: 20 February 2008; in revised form: 8 March 2008 / Accepted: 9 March 2008 / Published: 11 March 2008
Abstract: The unstable isomeric compounds 5-hydroxy-7-prop-2-en-(E)-ylidene-7,7adihydro-2H-cyclopenta[b]pyran-6-one (1) and 5-hydroxy-7-prop-2-en-(Z)-ylidene-7,7adihydro-2H-cyclopenta[b]pyran-6-one (2), previously described as antimicrobialmetabolites from the sponge Ulosa sp., were isolated and identified as major componentsof the ascidian Diplosoma virens. In this paper, full spectral data for 2 and complete 13CNMRdata for 1, based on 2D NMR measurements, are provided for the first time.Compounds 1 and 2 showed cytotoxity against HCT116 cells (human colorectal cancercells) by triggering apoptotic cell death.
Keywords: Diplosoma virens; HCT116; apoptosis; NMR
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Ogi, T.; Taira, J.; Margiastuti, P.; Ueda, K. Cytotoxic Metabolites from the Okinawan Ascidian Diplosoma virens. Molecules 2008, 13, 595-602.
Ogi T, Taira J, Margiastuti P, Ueda K. Cytotoxic Metabolites from the Okinawan Ascidian Diplosoma virens. Molecules. 2008; 13(3):595-602.
Ogi, Takayuki; Taira, Junsei; Margiastuti, Palupi; Ueda, Katsuhiro. 2008. "Cytotoxic Metabolites from the Okinawan Ascidian Diplosoma virens." Molecules 13, no. 3: 595-602.