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Open AccessCommunication
Molecules 2008, 13(3), 595-602; doi:10.3390/molecules13030595

Cytotoxic Metabolites from the Okinawan Ascidian Diplosoma virens

1
Department of Chemistry, Biology and Marine Science, University of the Ryukyus, Nishihara-cho Okinawa 903-0123, Japan
2
Okinawa Industrial Technology Center, Uruma-shi Okinawa 904-2234, Japan
3
Department of Bioresources Engineering, Okinawa National College of Technology, Nago-shi Okinawa 905-2192, Japan
*
Author to whom correspondence should be addressed.
Received: 20 February 2008 / Revised: 8 March 2008 / Accepted: 9 March 2008 / Published: 11 March 2008
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Abstract

The unstable isomeric compounds 5-hydroxy-7-prop-2-en-(E)-ylidene-7,7adihydro-2H-cyclopenta[b]pyran-6-one (1) and 5-hydroxy-7-prop-2-en-(Z)-ylidene-7,7adihydro-2H-cyclopenta[b]pyran-6-one (2), previously described as antimicrobialmetabolites from the sponge Ulosa sp., were isolated and identified as major componentsof the ascidian Diplosoma virens. In this paper, full spectral data for 2 and complete 13CNMRdata for 1, based on 2D NMR measurements, are provided for the first time.Compounds 1 and 2 showed cytotoxity against HCT116 cells (human colorectal cancercells) by triggering apoptotic cell death.
Keywords: Diplosoma virens; HCT116; apoptosis; NMR Diplosoma virens; HCT116; apoptosis; NMR
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Ogi, T.; Taira, J.; Margiastuti, P.; Ueda, K. Cytotoxic Metabolites from the Okinawan Ascidian Diplosoma virens. Molecules 2008, 13, 595-602.

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