Next Article in Journal
Docking Studies and Anti-inflammatory Activity of β-Hydroxy-β-arylpropanoic Acids
Previous Article in Journal
Polyphenol Content and Antioxidant Activity of Fourteen Wild Edible Fruits from Burkina Faso
Molecules 2008, 13(3), 595-602; doi:10.3390/molecules13030595
Communication

Cytotoxic Metabolites from the Okinawan Ascidian Diplosoma virens

1,2
,
3
,
1 and 1,*
1 Department of Chemistry, Biology and Marine Science, University of the Ryukyus, Nishihara-cho Okinawa 903-0123, Japan 2 Okinawa Industrial Technology Center, Uruma-shi Okinawa 904-2234, Japan 3 Department of Bioresources Engineering, Okinawa National College of Technology, Nago-shi Okinawa 905-2192, Japan
* Author to whom correspondence should be addressed.
Received: 20 February 2008 / Revised: 8 March 2008 / Accepted: 9 March 2008 / Published: 11 March 2008
View Full-Text   |   Download PDF [113 KB, uploaded 18 June 2014]   |  

Abstract

The unstable isomeric compounds 5-hydroxy-7-prop-2-en-(E)-ylidene-7,7adihydro-2H-cyclopenta[b]pyran-6-one (1) and 5-hydroxy-7-prop-2-en-(Z)-ylidene-7,7adihydro-2H-cyclopenta[b]pyran-6-one (2), previously described as antimicrobialmetabolites from the sponge Ulosa sp., were isolated and identified as major componentsof the ascidian Diplosoma virens. In this paper, full spectral data for 2 and complete 13CNMRdata for 1, based on 2D NMR measurements, are provided for the first time.Compounds 1 and 2 showed cytotoxity against HCT116 cells (human colorectal cancercells) by triggering apoptotic cell death.
Keywords: Diplosoma virens; HCT116; apoptosis; NMR Diplosoma virens; HCT116; apoptosis; NMR
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Ogi, T.; Taira, J.; Margiastuti, P.; Ueda, K. Cytotoxic Metabolites from the Okinawan Ascidian Diplosoma virens. Molecules 2008, 13, 595-602.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert