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Molecules 2008, 13(3), 556-566; doi:10.3390/molecules13030556
Article

Regioselective Synthesis of 1-(2,6-Dichloro-4-Trifluoromethylphenyl)- 4-Alkyl-1H-[1,2,3]-Triazoles

1,2,3, 3,4,* , 1,* , 3 and 3
Received: 9 November 2007; in revised form: 13 February 2008 / Accepted: 20 February 2008 / Published: 3 March 2008
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Abstract: A new and efficient method for the synthesis of 1-(2,6-dichloro-4-trifluoromethylphenyl)-4-alkyl-1H-[1,2,3]-triazoles by the room temperature 1,3-dipolarcycloaddition of (2-azido-1,3-dichloro-5-trifluoromethyl)benzene with terminal alkynes inthe presence of Cu (I) salt as catalyst is reported. All the reactions gave 1,4-disubstitutedproducts with high regioselectivity, as no 1,5-disubstituted product was formed. Thestructures of all the title compounds have been confirmed by elemental analysis, 1H- and13C-NMR and in addition, the structure of compound 5a was investigated by X-raycrystallography.
Keywords: 1; 3-Dipolar cycloaddition; 1; 2; 3-triazole; internal alkyne; regioselective 1; 3-Dipolar cycloaddition; 1; 2; 3-triazole; internal alkyne; regioselective
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Hu, H.; Zhang, A.; Ding, L.; Lei, X.; Zhang, L. Regioselective Synthesis of 1-(2,6-Dichloro-4-Trifluoromethylphenyl)- 4-Alkyl-1H-[1,2,3]-Triazoles. Molecules 2008, 13, 556-566.

AMA Style

Hu H, Zhang A, Ding L, Lei X, Zhang L. Regioselective Synthesis of 1-(2,6-Dichloro-4-Trifluoromethylphenyl)- 4-Alkyl-1H-[1,2,3]-Triazoles. Molecules. 2008; 13(3):556-566.

Chicago/Turabian Style

Hu, Huanan; Zhang, Anjiang; Ding, Lisheng; Lei, Xinxiang; Zhang, Lixue. 2008. "Regioselective Synthesis of 1-(2,6-Dichloro-4-Trifluoromethylphenyl)- 4-Alkyl-1H-[1,2,3]-Triazoles." Molecules 13, no. 3: 556-566.


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